dCas9 regulator to neutralize competition in CRISPRi circuits

Huang, HH; Bellato, M; Qian, YL; Cardenas, P; Pasotti, L; Magni, P; Del Vecchio, D

Del Vecchio, D (corresponding author), MIT, Dept Mech Engn, Cambridge, MA 02139 USA.; Del Vecchio, D (corresponding author), MIT, Synthet Biol Ctr, 77 Massachusetts Ave, Cambridge, MA 02139 USA.

NATURE COMMUNICATIONS, 2021; 12 (1):

Abstract

CRISPRi-mediated gene regulation allows simultaneous control of many genes. However, highly specific sgRNA-promoter binding is, alone, insufficient to......

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