Design, Synthesis and Biological Evaluation of Novel 1,2,5-Oxadiazol-3-Carboximidamide Derivatives as Indoleamine 2, 3-Dioxygenase 1 (IDO1) Inhibitors

Xia, ZF; Nan, YY; Liu, C; Lin, GY; Gu, KD; Chen, C; Zhao, WL; Ju, DW; Dong, XC

Dong, XC (corresponding author), Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai 201203, Peoples R China.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2020; 20 (13): 1592

Abstract

Background and Objective: Indoleamine-2,3-dioxygenase 1 (IDO1), which catalyzes the degradation of L-tryptophan (L-Trp) to N-formyl kynurenine (NFK) i......

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