The Cancer-Associated ATM R3008H Mutation Reveals the Link between ATM Activation and Its Exchange

Milanovic, M; Houghton, LM; Menolfi, D; Lee, JH; Yamamoto, K; Li, Y; Lee, BJ; Xu, J; Estes, VM; Wang, D; Mckinnon, PJ; Paull, TT; Zha, S

Zha, S (corresponding author), Columbia Univ, 1130 St Nicholas Ave,ICRC Room 503B, New York, NY 10032 USA.

CANCER RESEARCH, 2021; 81 (2): 426

Abstract

ATM kinase is a tumor suppressor and a master regulator of the DNA damage response. Most cancer-associated alterations to ATM are missense mutations a......

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