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The augment of regulatory T cells undermines the efficacy of anti-PD-L1 treatment in cervical cancer

期刊: BMC IMMUNOLOGY, 2021; 22 (1)

Background Immune checkpoint inhibitors have aroused great expectation of tumor eradication. However, the effect of anti-PD-L1 treatment for cervical ......

Circular RNA circFADS2 is overexpressed in sepsis and suppresses LPS-induced lung cell apoptosis by inhibiting the maturation of miR-15a-5p

期刊: BMC IMMUNOLOGY, 2021; 22 (1)

Background Circular RNA circFADS2 plays protective roles in LPS-induced inflammation, which promotes sepsis, suggesting its involvement in sepsis. Met......

Naive CD4(+) cell counts significantly decay and high HIV RNA levels contribute to immunological progression in long-term non-progressors infected with HIV by blood products: a cohort study

期刊: BMC IMMUNOLOGY, 2021; 22 (1)

Background Some long-term non-progressors (LTNPs) have decreasing CD4(+) T cell counts and progress to AIDS. Exploring which subsets of CD4(+) T cell ......

The inhibitory receptor Tim-3 fails to suppress IFN-gamma production via the NFAT pathway in NK-cell, unlike that in CD4(+) T cells

期刊: BMC IMMUNOLOGY, 2021; 22 (1)

Background T cell immunoglobulin and mucin domain-containing-3 (Tim-3) is a negative regulator expressed on T cells, and is also expressed on natural ......

Immunization with Pneumocystis carinii A12(1-85) antigen activates immune function against P. carinii

期刊: BMC IMMUNOLOGY, 2021; 22 (1)

Background Pneumocystis pneumonia (PcP), which is caused by Pneumocystis carinii, is a life-threatening infection that affects immunocompromised indiv......

Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis

期刊: BMC IMMUNOLOGY, 2021; 22 (1)

Background The anti-inflammatory effect of glycyrrhizin has been widely recognized, while the specific mechanism of glycyrrhizin in psoriasis remains ......

Serum IL-35 is decreased in overweight patients with rheumatoid arthritis: its correlation with Th1/Th2/Th17-related cytokines

期刊: BMC IMMUNOLOGY, 2021; 22 (1)

Background Obesity is correlated with worse drug responses and high disease activity in patients with rheumatoid arthritis (RA). Interleukin (IL)-35 i......

Pharmacological activation of rev-erb alpha suppresses LPS-induced macrophage M1 polarization and prevents pregnancy loss

期刊: BMC IMMUNOLOGY, 2021; 22 (1)

Background: Circadian rhythm is an important player for reproduction. Rev-erb alpha, a significant clock gene, is involved in regulating cell differen......

Differential long non-coding RNA expression profile and function analysis in primary Sjogren's syndrome

期刊: BMC IMMUNOLOGY, 2021; 22 (1)

Background Primary Sjogren's syndrome (pSS) is a chronic autoimmune disease characterized by abnormal immune cell activation. This study aimed to inve......

Soluble cytotoxic T-lymphocyte-associated antigen 4 (sCTLA-4) as a potential biomarker for diagnosis and evaluation of the prognosis in Glioma

期刊: BMC IMMUNOLOGY, 2021; 22 (1)

Background The cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is widely considered as a pivotal immune checkpoint molecule to suppress antitumor......

Upregulation of PD-1 expression on circulating CD8+but not CD4+T cells is associated with tuberculosis infection in health care workers

期刊: BMC IMMUNOLOGY, 2021; 22 (1)

Background Health care workers (HCWs) are at risk for occupationally acquired Mycobacterium tuberculosis infection and tuberculosis (TB) disease due t......

Assessment of CD27 expression on T-cells as a diagnostic and therapeutic tool for patients with smear-negative pulmonary tuberculosis

期刊: BMC IMMUNOLOGY, 2021; 22 (1)

Background There is a global focus on illness diagnosis in smear-negative and latent tuberculosis infectious populations (SN-TB and LTBI). CD27 has be......

Identification of active small-molecule modulators targeting the novel immune checkpoint VISTA

期刊: BMC IMMUNOLOGY, 2021; 22 (1)

Background Cancer immunotherapy has gained increasing popularity as a novel approach to treat cancer. A member of the B7 family, V-domain immunoglobul......

Variable clinical characteristics and laboratory results in five patients with Chinese Good's syndrome (thymoma and hypogammaglobulinemia): an 8-year retrospective analysis in a university hospital in China

期刊: BMC IMMUNOLOGY, 2021; 22 (1)

Background Good's syndrome (GS) is a rare secondary immunodeficiency disease presenting as thymoma and hypogammaglobulinemia. Due to its rarity, the d......

CD100 modulates cytotoxicity of CD8(+) T cells in patients with acute myocardial infarction

期刊: BMC IMMUNOLOGY, 2021; 22 (1)

Background CD100 is an immune semaphorin family member that highly expressed on T cells, which take part in the development of acute myocardial infarc......

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