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NAFLD as a continuous driver in the whole spectrum of vascular disease

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 163 ()

Vascular disease is the prime determinant to cardiovascular morbidities and mortalities, which comprises the early vascular damage and subsequent card......

JIF:4.275

Ventricular SK2 upregulation following angiotensin II challenge: Modulation by p21-activated kinase-1

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 164 ()

Effects of hypertrophic challenge on small-conductance, Ca2+-activated K+ (SK2) channel expression were explored in intact murine hearts, isolated ven......

JIF:4.275

KMT2B-dependent RFK transcription activates the TNF-?/NOX2 pathway and enhances ferroptosis caused by myocardial ischemia-reperfusion

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 173 ()

Epigenetic regulation such as histone modification is implicated in the pathogenesis of myocardial ischemia/ reperfusion injury (MIRI). Lysine-specifi......

JIF:4.275

Endothelial contribution to COVID-19: an update on mechanisms and therapeutic implications

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 164 ()

The global propagation of SARS-CoV-2 leads to an unprecedented public health emergency. Despite that the lungs are the primary organ targeted by COVID......

JIF:4.275

Coronary vessel formation in development and regeneration: origins and mechanisms

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 167 ()

Neovascularization of the ischemic myocardium following infarction is vital for the survival of cardiomyocytes and prevention of heart failure. Howeve......

JIF:4.275

Targeting endothelial dysfunction and inflammation

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 168 ()

Vascular endothelium maintains vascular homeostasis through liberating a spectrum of vasoactive molecules, both protective and harmful regulators of v......

JIF:4.275

Peli1 contributes to myocardial ischemia/reperfusion injury by impairing autophagy flux via its E3 ligase mediated ubiquitination of P62

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 173 ()

Autophagy flux is impaired during myocardial ischemia/reperfusion (M-I/R) via the accumulation of autopha-gosome and insufficient clearance, which exa......

JIF:4.275

Ion channels in stem cells and their roles in stem cell biology and vascular diseases

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 166 ()

Stem cell therapy may be a promising option for the treatment of vascular diseases. In recent years, significant progress has been made in stem cell r......

JIF:4.275

Matricellular proteins: Potential biomarkers and mechanistic factors in aortic aneurysms

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 169 ()

Aortic aneurysms, including thoracic aortic aneurysms and abdominal aortic aneurysms, are life-threatening macrovascular diseases with high mortality.......

JIF:4.275

Osteoblast MR deficiency protects against adverse ventricular remodeling after myocardial infarction

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 167 ()

Rationale: Mineralocorticoid receptor (MR) antagonists have been clinically used to treat heart failure. However, the underlying cellular and molecula......

JIF:4.275

Insights on aortic aneurysm and dissection: Role of the extracellular environment in vascular homeostasis

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 171 ()

Aortic aneurysm and dissection (AAD) is a life-threatening medical condition associated with high morbidity and mortality rates. Important mechanisms ......

JIF:4.275

PGE2 protects against heart failure through inhibiting TGF-I31 synthesis in cardiomyocytes and crosstalk between TGF-I31 and GRK2

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 172 ()

Inflammation plays a central role in the development of heart failure. Prostaglandin E2 (PGE2) is a key mediator of the inflammatory process in the ca......

JIF:4.275

Ferroptosis in heart failure

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 173 ()

With its complicated pathobiology and pathophysiology, heart failure (HF) remains an increasingly prevalent epidemic that threatens global human healt......

JIF:4.275

CXCR4 blockade in macrophage promotes angiogenesis in ischemic hindlimb by modulating autophagy

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 169 ()

Chemokine receptor CXCR4 plays a crucial role in leukocyte recruitment and inflammation regulation to influence tissue repair in ischemic diseases. He......

JIF:4.275

Methods of mouse cardiomyocyte isolation from postnatal heart

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 168 ()

Primary cardiomyocytes (CMs) are invaluable materials used to study in vitro cardiac physiology and pathophysiology. However, there is still a lack of......

JIF:4.275

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