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Pyroptosis and Airway Homeostasis Regulation

期刊: PHYSIOLOGICAL RESEARCH, 2023; 72 (1)

Pyroptosis is a form of cell death associated with inflammation. In the maintenance of airway homeostasis, pyroptosis goes through activation and asse......

Prenatal Exposure to Acrylamide Differently Affected the Sex Ratio, Aromatase and Apoptosis in Female Adult Offspring of Two Subsequent Generations

期刊: PHYSIOLOGICAL RESEARCH, 2023; 72 (1)

In the present study, we investigated the effect of acrylamide (ACR) exposure during pregnancy on the ovary of female adult offspring of two subsequen......

Mitochondria in Human Reproduction: Novel Paradigm in the Onset of Neurodegenerative Disorders

期刊: PHYSIOLOGICAL RESEARCH, 2023; 72 (2)

The disease progression of neurodegenerative disorders (NDD), including Alzheimer's, Parkinson's and Huntington's disease, is inextricably tied to mit......

Vitamin D, a Steroid Hormone, From Theory to Practice

期刊: PHYSIOLOGICAL RESEARCH, 2023; 72 (2)

Recently deceased professor Luboslav Starka was a world-renowned doctor who devoted his whole life to the study and therapeutic use of steroids, and w......

Research Progress Into Adipose Tissue Macrophages and Insulin Resistance

期刊: PHYSIOLOGICAL RESEARCH, 2023; 72 (3)

In recent years, there has been an increasing incidence of metabolic syndrome, type 2 diabetes, and cardiovascular events related to insulin resistanc......

Tumor-Infiltrating Lymphocytes and Adoptive Cell Therapy: State of the Art in Colorectal, Breast and Lung Cancer

期刊: PHYSIOLOGICAL RESEARCH, 2023; 72 ()

Our knowledge of tumor-infiltrating lymphocytes (TILs) is dramatically expanding. These cells have proven prognostic and therapeutic value for many ca......

Postprandial Triglyceride, Glucose and Insulin Levels 10 Years After Bariatric Surgery in Women With Severe Obesity - A Pilot Study: Part 2-Biliopancreatic Diversion

期刊: PHYSIOLOGICAL RESEARCH, 2023; 72 ()

Obesity significantly increases the risk of developing metabolic and cardiovascular diseases. The most effective management tool for both obesity and ......

Sex Differences in Plasma Metabolites in a Guinea Pig Model of Allergic Asthma

期刊: PHYSIOLOGICAL RESEARCH, 2023; 72 (6)

Sex seems to be a contributing factor in the pathogenesis of bronchial asthma. This study aimed to find sex-related differences in metabolome measured......

Supplementation-Induced Change in Muscle Carnosine is Paralleled by Changes in Muscle Metabolism, Protein Glycation and Reactive Carbonyl Species Sequestering

期刊: PHYSIOLOGICAL RESEARCH, 2023; 72 (1)

Carnosine is a performance-enhancing food supplement with a potential to modulate muscle energy metabolism and toxic metabolites disposal. In this stu......

Role of 5-HT2 Receptors Family in the Allergy-Induced Increased Aorta Contractile Responses to 5-HT

期刊: PHYSIOLOGICAL RESEARCH, 2023; 72 (1)

Asthma poses an increased risk for cardiovascular disorders, suggesting that allergy, which is an underlying process in asthma, causes atypical functi......

Age-Dependent Effects of Remote Preconditioning in Hypertensive Rat Hearts are Associated With Activation of RISK Signaling

期刊: PHYSIOLOGICAL RESEARCH, 2023; 72 ()

Remote ischemic preconditioning (RIPC) represents one of the forms of innate cardioprotection. While being effective in animal models, its application......

Double-Edged Sword Effect of Reactive Oxygen Species (ROS) in Tumor Development and Carcinogenesis

期刊: PHYSIOLOGICAL RESEARCH, 2023; 72 (3)

Reactive oxygen species (ROS) are small reactive molecules produced by cellular metabolism and regulate various physiological and pathological functio......

Magnetic Resonance Imaging Techniques for Indirect Assessment of Myelin Content in the Brain Using Standard T1w and T2w MRI Sequences and Postprocessing Analysis

期刊: PHYSIOLOGICAL RESEARCH, 2023; 72 (6)

Magnetic Resonance Imaging (MRI) has revolutionized our ability to non-invasively study the brain's structural and functional properties. However, det......

Unilateral Nephrectomized SHR/NDmcr-cp Rat Shows a Progressive Decline of Glomerular Filtration With Tubular Interstitial Lesions

期刊: PHYSIOLOGICAL RESEARCH, 2023; 72 (2)

In patients with diabetic kidney disease (DKD), the estimated glomerular filtration rate (eGFR) or creatinine clearance rate (Ccr) is always used as a......

Effect of Laparoscopic Sleeve Gastrectomy on Serum Adipokine Levels

期刊: PHYSIOLOGICAL RESEARCH, 2023; 72 ()

Bariatric procedures are considered to be the most effective treatment options for obesity. One of them is laparoscopic sleeve gastrectomy (LSG), whic......

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