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LY294002 ameliorates psoriatic skin inflammation in mice via blocking the Notch1/Hes1-PTEN/AKT/IL-17A feedback loop

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2023; 213 (1)

(IL)-17A, the effective factor of Th17 cells, acts an important pathological role in the pathogenesis of psoriasis. Notch1/hairy and split 1 (Hes1) an......

Harnessing the power of memory-like NK cells to fight cancer

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2023; 212 (3)

The success of NK cells to eliminate tumors depends on their strong immunosurveillance capacity. Tumor microenvironment promotes the release of inhibi......

Coexistence of apoptosis, pyroptosis, and necroptosis pathways in celiac disease

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2023; 214 (3)

Usually, the massive elimination of cells under steady-state conditions occurs by apoptosis, which is also acknowledged to explain the loss of enteroc......

Soluble wild-type ACE2 molecules inhibit newer SARS-CoV-2 variants and are a potential antiviral strategy to mitigate disease severity in COVID-19

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2023; 214 (3)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease of 2019 (COVID-19), has caused havoc aroun......

Leucine-rich repeat kinase 2 promotes the development of experimental severe acute pancreatitis

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2023; 214 (2)

Translocation of gut bacteria into the pancreas promotes the development of severe acute pancreatitis (SAP). Recent clinical studies have also highlig......

The CXCL10-CXCR3 axis plays an important role in Kawasaki disease

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2023; ()

The precise pathogenesis of Kawasaki disease remains unknown. In an attempt to elucidate the pathogenesis of KD through the analysis of acquired immun......

The comprehensive role of apoptosis inhibitor of macrophage (AIM) in pathological conditions

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2023; 212 (3)

CD5L/AIM (apoptosis inhibitor of macrophage), as an important component in maintaining tissue homeostasis and inflammation, is mainly produced and sec......

HTNV infection induces activation and deficiency of CD8+MAIT cells in HFRS patients

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2023; 211 (1)

Hantaan virus (HTNV) infection causes an epidemic of hemorrhagic fever with renal syndrome (HFRS) mainly in Asia. Mucosal-associated invariant T (MAIT......

Compartment-driven imprinting of intestinal CD4 T cells in inflammatory bowel disease and homeostasis

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2023; 214 (3)

The mucosal immune system is implicated in the etiology and progression of inflammatory bowel diseases. The lamina propria and epithelium of the gut m......

MAIT cells in bacterial infectious diseases: heroes, villains, or both?

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2023; 214 (2)

Due to the aggravation of bacterial drug resistance and the lag in the development of new antibiotics, it is crucial to develop novel therapeutic regi......

A novel selective spleen tyrosine kinase inhibitor SKI-O-703 (cevidoplenib) ameliorates lupus nephritis and serum-induced arthritis in murine models

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2023; 211 (1)

Orally administered SKI-O-703, a new Syk inhibitor, reduces lupus nephritis-like manifestations in NZB/W mice. Spleen tyrosine kinase (Syk) plays a pi......

miR-132-3p regulates antibody-mediated complement-dependent cytotoxicity in colon cancer cells by directly targeting CD55

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2023; 211 (1)

miR-132-3p regulates CD55 expression by directly targeting the 3MODIFIER LETTER PRIME-UTR of CD55, leading to changes in cell sensitivity to Ab-mediat......

Galectin-9 in synergy with NF-κB inhibition restores immune regulatory capability in dendritic cells of subjects with food allergy

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2023; 213 (2)

The pathogenesis of immune tolerance disruption is not fully understood. Galectin-9 (Gal9) has immune regulatory functions. The objective of the prese......

The pathogenesis of multiple sclerosis: a series of unfortunate events

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2023; 214 (1)

Multiple sclerosis (MS) is characterized by the chronic inflammatory destruction of myelinated axons in the central nervous system. Several ideas have......

Shift in the B cell subsets between children with type 1 diabetes and/or celiac disease

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2023; ()

Our purpose was to characterize the pattern of B cell subsets in children with a combined diagnosis of type 1 diabetes (T1D) and celiac disease (C) si......

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