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HOXA9 transcription factor is a double-edged sword: from development to cancer progression

期刊: CANCER AND METASTASIS REVIEWS, 2023; ()

The HOXA9 transcription factor serves as a molecular orchestrator in cancer stemness, epithelial-mesenchymal transition (EMT), metastasis, and generat......

Regulation and targeting of SREBP-1 in hepatocellular carcinoma

期刊: CANCER AND METASTASIS REVIEWS, 2023; ()

Hepatocellular carcinoma (HCC) is an increasing burden on global public health and is associated with enhanced lipogenesis, fatty acid uptake, and lip......

The genetic profile and molecular subtypes of human pseudomyxoma peritonei and appendiceal mucinous neoplasms: a systematic review

期刊: CANCER AND METASTASIS REVIEWS, 2023; 42 (1)

Pseudomyxoma peritonei (PMP) is a rare, progressive, slowly growing neoplastic condition which is poorly understood, with a 5-year progression-free su......

Molecular profile of metastasis, cell plasticity and EMT in pancreatic cancer: a pre-clinical connection to aggressiveness and drug resistance

期刊: CANCER AND METASTASIS REVIEWS, 2023; ()

The metastasis is a multistep process in which a small proportion of cancer cells are detached from the colony to enter into blood cells for obtaining......

Targeting microRNAs as a promising anti-cancer therapeutic strategy against traffic-related air pollution-mediated lung cancer

期刊: CANCER AND METASTASIS REVIEWS, 2023; ()

Air pollutants are increasingly emitted into the atmosphere because of the high dependency of humans on fossil-derived fuels. Wind speed and direction......

Nanoparticle-mediated cancer cell therapy: basic science to clinical applications

期刊: CANCER AND METASTASIS REVIEWS, 2023; 42 (3)

Every sixth person in the world dies due to cancer, making it the second leading severe cause of death after cardiovascular diseases. According to WHO......

Considerations for modelling diffuse high-grade gliomas and developing clinically relevant therapies

期刊: CANCER AND METASTASIS REVIEWS, 2023; 42 (2)

Diffuse high-gradegliomas contain some of the most dangerous human cancers that lack curative treatment options. The recent molecular stratification o......

B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention

期刊: CANCER AND METASTASIS REVIEWS, 2023; ()

B7-H3 (B7 homology 3 protein) is an important transmembrane immunoregulatory protein expressed in immune cells, antigen-presenting cells, and tumor ce......

Sam68 is a druggable vulnerability point in cancer stem cells

期刊: CANCER AND METASTASIS REVIEWS, 2023; ()

Sam68 (Src associated in mitosis of 68 kDa) is an RNA-binding and multifunctional protein extensively characterized in numerous cellular functions, su......

Tissue-derived extracellular vesicles in cancer progression: mechanisms, roles, and potential applications

期刊: CANCER AND METASTASIS REVIEWS, 2023; ()

Extracellular vesicles (EVs) are small lipid bilayer-enclosed vesicles that mediate vital cellular communication by transferring cargo between cells. ......

Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments

期刊: CANCER AND METASTASIS REVIEWS, 2023; ()

Colorectal cancer is the third most common and the second deadliest cancer worldwide. To date, colorectal cancer becomes one of the most important cha......

Hepatocellular carcinoma: molecular mechanism, targeted therapy, and biomarkers

期刊: CANCER AND METASTASIS REVIEWS, 2023; 42 (3)

Hepatocellular carcinoma (HCC) is a common malignancy and one of the leading causes of cancer-related death. The biological process of HCC is complex,......

The strict regulation of HIF-1α by non-coding RNAs: new insight towards proliferation, metastasis, and therapeutic resistance strategies

期刊: CANCER AND METASTASIS REVIEWS, 2023; ()

The hypoxic environment is prominently witnessed in most solid tumors and is associated with the promotion of cell proliferation, epithelial-mesenchym......

Potential biomarkers for immunotherapy in non-small-cell lung cancer

期刊: CANCER AND METASTASIS REVIEWS, 2023; 42 (3)

For individuals with advanced or metastatic non-small cell lung cancer (NSCLC), the primary treatment is platinum-based doublet chemotherapy. Immune c......

Metabolic factors associated with the prognosis of oligometastatic patients treated with stereotactic body radiotherapy

期刊: CANCER AND METASTASIS REVIEWS, 2023; 42 (3)

Over the past two decades, it has been established that cancer patients with oligometastases, i.e., only a few detectable metastases confined to one o......

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