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Two-dimensional molecular condensation in cell signaling and mechanosensing

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2023; 55 (7)

Membraneless organelles (MLO) regulate diverse biological processes in a spatiotemporally controlled manner spanning from inside to outside of the cel......

The protective effect of the mitochondrial-derived peptide MOTS-c on LPS-induced septic cardiomyopathy

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2023; 55 (2)

Septic cardiomyopathy is associated with mechanisms such as excessive inflammation, oxidative stress, regulation of calcium homeostasis, endothelial d......

5-HMF attenuates inflammation and demyelination in experimental autoimmune encephalomyelitis mice by inhibiting the MIF-CD74 interaction

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2023; 55 (8)

The neuroprotective role of 5-hydroxymethyl-2-furfural (5-HMF) has been demonstrated in a variety of neurological diseases. The aim of this study is t......

MFAP2 promotes the progression of oral squamous cell carcinoma by activating the Wnt/β-catenin signaling pathway through autophagy

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2023; 55 (9)

Microfibrillar-associated protein 2 (MFAP2) is a small glycoprotein that is involved in vascular development and metabolic disease. The present study ......

PGAM5 deacetylation mediated by SIRT2 facilitates lipid metabolism and liver cancer proliferation

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2023; 55 (9)

Tumor metabolic reprogramming and epigenetic modification work together to promote tumorigenesis and development. Protein lysine acetylation, which af......

TXNIP aggravates cardiac fibrosis and dysfunction after myocardial infarction in mice by enhancing the TGFB1/Smad3 pathway and promoting NLRP3 inflammasome activation

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2023; 55 (12)

Myocardial infarction (MI) results in high mortality. The size of fibrotic scar tissue following MI is an independent predictor of MI outcomes. Thiore......

Activation of the 5-hydroxytryptamine 4 receptor ameliorates tight junction barrier dysfunction in the colon of type 1 diabetic mice

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2023; 55 (12)

Hyperglycemia drives dysfunction of the intestinal barrier. 5-Hydroxytryptaine 4 receptor (5-HT4R) agonists have been considered therapeutics for cons......

Inhibitory effect of calycosin on breast cancer cell progression through downregulating lncRNA HOTAIR and downstream targets: HuR and IGF2BP1

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2023; 55 (2)

Breast cancer is the most commonly diagnosed cancer worldwide. Previously, we reported that calycosin, a typical isoflavone phytoestrogen, triggers ap......

A direct interaction between CENTLEIN and RABIN8 is required for primary cilium formation

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2023; 55 (9)

Primary cilia are formed in nearly all growth-arrested cells and are essential for mammalian development and tissue homeostasis. Defects in primary ci......

LincRNA-P21 knockdown facilitates esophageal squamous cell carcinoma cell progression by upregulating cadherin 5 via YTH domain containing 1

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2023; 55 (11)

LincRNA-P21 is a tumor suppressor in esophageal squamous cell carcinoma (ESCC). Cell adhesion modules play vital roles in cell-cell and cell-extracell......

The pseudogene DUXAP10 contributes to gefitinib resistance in NSCLC by repressing OAS2 expression

期刊: ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2023; 55 (1)

Gefitinib, an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI),is the currently recommended first-line therapy for advanced EGFR-......

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