Arid1a promotes thymocyte development through β-selection-dependent and β-selection-independent mechanisms.
Yang X, Wang X, Lei L, Su Y, Zou Y, Liu H, Jiao A, Zhang C, Liu J, Li W, Ding R, Zhou X, Shi L, Zhang D, Sun C, Zhang B.
Yang X, et al.
Immunology. 2022 Apr;165(4):402-413. doi: 10.1111/imm.13440. Epub 2021 Dec 27.
Immunology. 2022.
PMID: 34921692
Free article.
The expression of intracellular TCRbeta is significantly decreased in Arid1a-deficient DN4 cells compared with WT cells. OT1 transgenic TCR can rescue the defect in the transition from DN3 to DN4 stages, but not from DN to DP stages. Furthermore, we observed a comparabl …
The expression of intracellular TCRbeta is significantly decreased in Arid1a-deficient DN4 cells compared with WT cells. OT1 transgen …