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Pyro(phospho)mania
Understanding the role of pyrophosphorylation requires specific analytical strategies to discriminate it from protein phosphorylation. A custom workflow reveals that nucleolar protein pyrophosphorylation in human cells regulates the transcription of ribosomal DNA.
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Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning
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β-Lactone formation during product release from a nonribosomal peptide synthetase
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Molecular recording of calcium signals via calcium-dependent proximity labeling
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Extensive protein pyrophosphorylation revealed in human cell lines