Announcements
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A call for ecology papers
Open for submissions -
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Quantitative profiling of regulatory DNA activity at single-cell resolution
We developed a two-pronged strategy to functionally probe the enormous repertoire of noncoding DNA within genomes. Our approach markedly improved signal-to-noise ratio and successfully intersected single-cell genomics with reporter assays. The result delivers a multiplex and highly quantitative readout of regulatory sequences’ activity in dynamic and multicellular systems.
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Method of the Year 2023: Methods for modeling development
Methods for modeling development is our Method of the Year 2023, for the remarkable insights that recent methodological advances have enabled in our understanding of the molecular mechanisms of human embryogenesis.
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CODA: quantitative 3D reconstruction of large tissues at cellular resolution
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Molecular pixelation: spatial proteomics of single cells by sequencing
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Unveiling microbial diversity: harnessing long-read sequencing technology
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Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput