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Int J Nanomed：使用介孔二氧化硅制备多功能膜控靶向给药系统

2017-12-04 MedSci MedSci原创

介孔二氧化硅膜控靶向给药
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目前用于药物输送的纳米粒子系统具有非特异性靶向、过早释放、弱选择性和不良治疗效果等缺点，为了克服这些缺陷，我们制备了天然材料修饰的纳米粒子作为多功能膜控制靶向药物递送系统。经检测限时，这种涂覆有膜的纳米复合材料具有良好的生物相容性，且具有特异性肿瘤靶向和对刺激响应的双重特征，改善了传输效率和药物的控释。介孔二氧化硅纳米粒子（MSNs）是一种已知的生物相容性好和载药量高的载体，因此选择MSNs作为模

目前用于药物输送的纳米粒子系统具有非特异性靶向、过早释放、弱选择性和不良治疗效果等缺点，为了克服这些缺陷，我们制备了天然材料修饰的纳米粒子作为多功能膜控制靶向药物递送系统。

经检测限时，这种涂覆有膜的纳米复合材料具有良好的生物相容性，且具有特异性肿瘤靶向和对刺激响应的双重特征，改善了传输效率和药物的控释。介孔二氧化硅纳米粒子（MSNs）是一种已知的生物相容性好和载药量高的载体，因此选择MSNs作为模型药物容器和载体。

采用高分子电解质复合法将对酸性肿瘤微环境敏感的壳聚糖（CS），识别肿瘤细胞表面表达的叶酸受体的叶酸修饰的CS和靶向CD44受体的多糖透明质酸合并构建此膜。进一步对纳米复合材料的结构以及在pH敏感膜开关控制下的药物释放行为进行了表征，并评估了该体系在体外的抗肿瘤效果。

综上所述，该研究结果为设计和制造具新的肿瘤靶向疗法的新型膜控纳米粒子提供了基础。

原始出处：

Yan Hu, Lei Ke, et al., Natural material-decorated mesoporous silica nanoparticle container for multifunctional membrane-controlled targeted drug delivery. Int J Nanomedicine. 2017; 12: 8411–8426. doi:  10.2147/IJN.S148438

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    2018-06-25 luckyshitiancai_42705692

    #介孔#

    0

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    2018-07-13 ms7405317358118777

    #靶向给药#

    0

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    2018-03-15 guojianrong

    #二氧化硅#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1664828, encodeId=8bd91664828f5, content=<a href='/topic/show?id=78dd2529262' target=_blank style='color:#2F92EE;'>#介孔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25292, encryptionId=78dd2529262, topicName=介孔)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b9b025850974, createdName=luckyshitiancai_42705692, createdTime=Mon Jun 25 22:14:00 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038315, encodeId=8992203831500, content=<a href='/topic/show?id=8736999382a' target=_blank style='color:#2F92EE;'>#靶向给药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99938, encryptionId=8736999382a, topicName=靶向给药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/xkicoVBAnV4HxvdCqC1viaW8wdLQdN9hVP9icgqqDsxC6UVPjfhogdfc2iaU1xNUMVlFl5QicicWrjWQBTsVye5ngOQQ/132, createdBy=f92f2500185, createdName=ms7405317358118777, createdTime=Fri Jul 13 03:14:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1744712, encodeId=f8c51e44712ce, content=<a href='/topic/show?id=797023963a3' target=_blank style='color:#2F92EE;'>#二氧化硅#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23963, encryptionId=797023963a3, topicName=二氧化硅)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=61ab35418786, createdName=guojianrong, createdTime=Thu Mar 15 23:14:00 CST 2018, time=2018-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267246, encodeId=a0c626e246aa, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed Dec 06 12:27:22 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608321, encodeId=53ff160832176, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Dec 06 10:14:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267084, encodeId=07fb26e084ee, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Dec 05 22:45:40 CST 2017, time=2017-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266795, encodeId=de50266e9508, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Dec 04 19:59:51 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266785, encodeId=676c266e8566, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Mon Dec 04 19:48:48 CST 2017, time=2017-12-04, status=1, ipAttribution=)]
    2017-12-06 天涯183

    非常好的文章.学习了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1664828, encodeId=8bd91664828f5, content=<a href='/topic/show?id=78dd2529262' target=_blank style='color:#2F92EE;'>#介孔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25292, encryptionId=78dd2529262, topicName=介孔)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b9b025850974, createdName=luckyshitiancai_42705692, createdTime=Mon Jun 25 22:14:00 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038315, encodeId=8992203831500, content=<a href='/topic/show?id=8736999382a' target=_blank style='color:#2F92EE;'>#靶向给药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99938, encryptionId=8736999382a, topicName=靶向给药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/xkicoVBAnV4HxvdCqC1viaW8wdLQdN9hVP9icgqqDsxC6UVPjfhogdfc2iaU1xNUMVlFl5QicicWrjWQBTsVye5ngOQQ/132, createdBy=f92f2500185, createdName=ms7405317358118777, createdTime=Fri Jul 13 03:14:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1744712, encodeId=f8c51e44712ce, content=<a href='/topic/show?id=797023963a3' target=_blank style='color:#2F92EE;'>#二氧化硅#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23963, encryptionId=797023963a3, topicName=二氧化硅)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=61ab35418786, createdName=guojianrong, createdTime=Thu Mar 15 23:14:00 CST 2018, time=2018-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267246, encodeId=a0c626e246aa, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed Dec 06 12:27:22 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608321, encodeId=53ff160832176, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Dec 06 10:14:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267084, encodeId=07fb26e084ee, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Dec 05 22:45:40 CST 2017, time=2017-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266795, encodeId=de50266e9508, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Dec 04 19:59:51 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266785, encodeId=676c266e8566, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Mon Dec 04 19:48:48 CST 2017, time=2017-12-04, status=1, ipAttribution=)]
    2017-12-06 ms3994565386320060

    #Med#

    0

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    2017-12-05 1e1b8538m79(暂无匿称)

    不错的文章值得推荐

    0

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    2017-12-04 惠映实验室

    学习了.谢谢.

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1664828, encodeId=8bd91664828f5, content=<a href='/topic/show?id=78dd2529262' target=_blank style='color:#2F92EE;'>#介孔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25292, encryptionId=78dd2529262, topicName=介孔)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b9b025850974, createdName=luckyshitiancai_42705692, createdTime=Mon Jun 25 22:14:00 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038315, encodeId=8992203831500, content=<a href='/topic/show?id=8736999382a' target=_blank style='color:#2F92EE;'>#靶向给药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99938, encryptionId=8736999382a, topicName=靶向给药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/xkicoVBAnV4HxvdCqC1viaW8wdLQdN9hVP9icgqqDsxC6UVPjfhogdfc2iaU1xNUMVlFl5QicicWrjWQBTsVye5ngOQQ/132, createdBy=f92f2500185, createdName=ms7405317358118777, createdTime=Fri Jul 13 03:14:00 CST 2018, time=2018-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1744712, encodeId=f8c51e44712ce, content=<a href='/topic/show?id=797023963a3' target=_blank style='color:#2F92EE;'>#二氧化硅#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23963, encryptionId=797023963a3, topicName=二氧化硅)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=61ab35418786, createdName=guojianrong, createdTime=Thu Mar 15 23:14:00 CST 2018, time=2018-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267246, encodeId=a0c626e246aa, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed Dec 06 12:27:22 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608321, encodeId=53ff160832176, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Dec 06 10:14:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267084, encodeId=07fb26e084ee, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Dec 05 22:45:40 CST 2017, time=2017-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266795, encodeId=de50266e9508, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Dec 04 19:59:51 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266785, encodeId=676c266e8566, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Mon Dec 04 19:48:48 CST 2017, time=2017-12-04, status=1, ipAttribution=)]
    2017-12-04 天涯183

    非常好的文章.学习了

    0

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