Clin Endocrinol:尿碘/肌酐比值估计尿碘排泄量

2016-11-18 MedSci MedSci原创

研究对象为中国学龄期儿童,研究目的是评估使用尿碘/肌酐比值(UI/Cr)估计点尿液样本中尿碘排泄量(UIE)的有效性。 这项横断面研究在1个月内收集了参与者的两次重复24小时尿液和点尿液样本。测量尿碘浓度(UIC)、尿肌酐浓度(UCr)、尿量(Uvol)。根据24-h UIC乘以24-h Uvol计算24-h UIE;点尿液样本中的UI/Cr乘以24-h尿肌酐排泄量(24-h UCrE)估计

研究对象为中国学龄期儿童,研究目的是评估使用尿碘/肌酐比值(UI/Cr)估计点尿液样本中尿碘排泄量(UIE)的有效性。

这项横断面研究在1个月内收集了参与者的两次重复24小时尿液和点尿液样本。测量尿碘浓度(UIC)、尿肌酐浓度(UCr)、尿量(Uvol)。根据24-h UIC乘以24-h Uvol计算24-h UIE;点尿液样本中的UI/Cr乘以24-h尿肌酐排泄量(24-h UCrE)估计24-h UIE。

两次重复样本中的24-h Uvol无显著性差异(P=0.70),不过点尿液样本中的UIC、24-h UIC、UI/Cr和24-h UIE有显著性差异(P<0.05)。

第一次收集的样本中,估计的24-h UIE值为247 (136-431) μg/d,低于测量的24-h UIE值,为329 (183-536) μg/d (P<0.001);不过第二次收集的样本中,没有发现估计的24-h UIE值与测量的24-h UIE值的差异(分别为355 (168-624) μg/d和350 (181-615) μg/d)。

第一次采样中,点尿样中的UIC (r=0.57, P<0.001)、UI/Cr (r=0.63, P<0.001)和估计的24-h UIE (r=0.83, P<0.001)与测量的24-h UIE水平密切相关。

同样,第二次采样中,点尿样中的UIC (r=0.60, P<0.001)、UI/Cr (r=0.72, P<0.001)和估计的24-h UIE (r=0.89, P<0.001)也与测量的24-h UIE水平密切相关。

估计的24-h UIE值与测量的24-h UIE值具有中度至良好的一致性,Kappa值分别为0.55和0.66。

结果表明,对于中国学龄期儿童,根据点尿样的UI/Cr比值而估计的24-h UIE,可以替代24小时尿液样本中计算出的24-h UIE。

原始出处:

Wen Chen, Xiang Li,et al.Urinary iodine excretion (UIE) estimated by iodine/creatinine ratio from spot urine in Chinese school-age children.Clinical Endocrinology.Accepted manuscript online: 16 November 2016

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    2016-12-30 维他命
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    2016-11-20 虈亣靌

    讲的好,学习一下

    0

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    2016-11-20 俅侠
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    2016-11-19 136****0753赵

    值得学习。

    0

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    2016-11-19 大爰

    学习并分享感谢!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1743849, encodeId=a6f91e43849bf, content=<a href='/topic/show?id=9b185665065' target=_blank style='color:#2F92EE;'>#排泄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56650, encryptionId=9b185665065, topicName=排泄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d01c35235377, createdName=维他命, createdTime=Fri Dec 30 11:20:00 CST 2016, time=2016-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066732, encodeId=d74e2066e3226, content=<a href='/topic/show?id=c6914e4851b' target=_blank style='color:#2F92EE;'>#尿碘排泄量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47485, encryptionId=c6914e4851b, topicName=尿碘排泄量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Thu Oct 26 17:20:00 CST 2017, time=2017-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157065, encodeId=54d615e0653c, content=讲的好,学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Nov 20 13:40:46 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293417, encodeId=bb0e129341e95, content=<a href='/topic/show?id=1d44810e5f7' target=_blank style='color:#2F92EE;'>#肌酐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81075, encryptionId=1d44810e5f7, topicName=肌酐)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5a6b240, createdName=俅侠, createdTime=Sun Nov 20 02:20:00 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332115, encodeId=0ede1332115aa, content=<a href='/topic/show?id=d61c4e48454' target=_blank style='color:#2F92EE;'>#尿碘/肌酐比值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47484, encryptionId=d61c4e48454, topicName=尿碘/肌酐比值)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85152500072, createdName=124987c6m36暂无昵称, createdTime=Sun Nov 20 02:20:00 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156864, encodeId=13011568643d, content=值得学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLMzGpMQ8w4I7FpiblCXNcmI6O7TDINutbaicEUpoYFR1rWqn3kTbulfMhT0iaPFurLz2ddEcWe3BiciaQ/0, createdBy=5f6e1724878, createdName=136****0753赵, createdTime=Sat Nov 19 11:55:46 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156771, encodeId=69f7156e71bb, content=学习并分享感谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Nov 19 07:59:59 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156592, encodeId=91ac156592e2, content=查尿碘/尿肌酐比值,判断儿童是否缺碘,好方法。, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Nov 18 11:40:00 CST 2016, time=2016-11-18, status=1, ipAttribution=)]
    2016-11-18 1e0f8808m18(暂无匿称)

    查尿碘/尿肌酐比值,判断儿童是否缺碘,好方法。

    0