血脂异常老年人使用他汀类药物中国专家共识发布

2015-05-11 佚名 医师报

为进一步加强我国老年人动脉粥样硬化性心血管病(ASCVD)的防治工作,借鉴今年发布的国际血脂管理指南和临床证据,近日,我国部分老年心脑血管病专家更新了2010年版《血脂异常老年人使用他汀类药物中国专家共识》。(中华内科杂志.2015,54:467) 共识指出,他汀类药物治疗可降低ASCVD的病死率,减少心血管事件。由于老年人心血管病患病率高,发生心血管事件的危险更大,他汀类药物治疗带来的

为进一步加强我国老年人动脉粥样硬化性心血管病(ASCVD)的防治工作,借鉴今年发布的国际血脂管理指南和临床证据,近日,我国部分老年心脑血管病专家更新了2010年版《血脂异常老年人使用他汀类药物中国专家共识》。(中华内科杂志.2015,54:467) 

共识指出,他汀类药物治疗可降低ASCVD的病死率,减少心血管事件。由于老年人心血管病患病率高,发生心血管事件的危险更大,他汀类药物治疗带来的绝对获益更大。目前,缺乏专为高龄(80岁以上)老年人设计的前瞻、随机对照大规模临床试验,缺乏大剂量他汀类药物治疗使老年人获益的临床证据。
 
低密度脂蛋白胆固醇是老年人血脂异常管理的首要目标,非低密度脂蛋白胆固醇是次要目标。共识建议调整饮食结构、采取健康的生活方式作为治疗老年人血脂异常的基本措施,他汀类药物为首选调脂药。建议根据患者心血管病的危险分层及个体特点,充分评估调脂治疗的利弊,合理选择调脂药物。 

他汀类药物相关的肌肉、肝脏、肾脏及新发糖尿病等不良反应随药物剂量增大而增加。因此,ASCVD老人使用他汀类药物应从小或中等剂量开始,后续根据疗效调整剂量。 

使用他汀类药物使血脂达标后,应坚持长期用药,可根据血脂水平调整剂量甚至更换不同他汀类药物,如无特殊原因不应停药。停用他汀类药物后血脂升高甚至反跳,使心血管事件及死亡率明显增加。

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    2015-05-11 hbwang006

    有机会看看原文

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