Chest:小儿并发肺炎后住院时间延长的预测因子。

2017-09-28 fengxiangxin MedSci原创

小儿社区获得性复杂性肺炎(pcacp)的特点是其临床过程延长,但这根据不同情况可能存在很大的可变性。

小儿社区获得性复杂性肺炎(pcacp)的特点是其临床过程延长,但这根据不同情况可能存在很大的可变性。

为了开发和验证能够预测 PCACP 延长住院的临床预测工具,研究者开展了一个多中心观察性研究。原始队列和验证队列分别包含144例和169例PCACP患者,他们均为1997-2017年间于3个三级医院住院的患者。Logistic回归分析被用来确定与长期住院相关的参数,以及为了构建一个有用的临床工具,开发验证出一个预测模型。

研究中,分析发现胸腔积液中较高水平的乳酸脱氢酶(p<0.026)和较低的血糖水平(p=0.018)与住院时间延长显著相关。

于是研究者建立了预测性逐步logistic回归模型,并应用于验证队列。ROC曲线下面积(AUC)表明,此模型保持了较高的预测价值(AUC原始数据 vs 验证数据= 0.77(95% CI 0.66-0.87)vs 0.82(95% CI 0.72-0.91))。根据以上数据,研究者建立了以下预测临床工具:

结合胸水LDH > 1000u/L和胸水葡萄糖<1mmol/L或胸水LDH>2000U/ L和胸水葡萄糖<2mmol/L或胸水LDH>3000U/L和胸水葡萄糖<3mmol/L预测住院时间延长。积极和消极预测值分别为78%(95% CI 0.71-0.85)和73%(95% CI 0.59-0.85)。

因此,在儿童中,胸腔积液中LDH和葡萄糖含量能够有效评估PCACP的严重程度。并且,此项研究中开发的模型能够准确地识别出那些需要延长住院时间的患者。

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    2017-12-22 丁鹏鹏
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    2018-04-15 Smile2680
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