J Am Acad Dermatol:小儿恶性黑色素瘤常模仿皮肤良性病变:回顾性研究

2016-07-24 Mechront 译 MedSci原创

背景:儿童黑色素瘤可能会被误诊,因为它的稀有性和不典型的表现。目的:试图探究儿童黑色素瘤与Breslow深度和临床行为的相关性,识别皮肤科医生和非皮肤科医生的误诊情况。方法:对2000-2015年梅奥诊所诊断为原发性皮肤黑色素瘤的≤21岁患者进行回顾性研究。结果:与临床表现为恶性黑色素瘤相比,模仿皮肤良性病变的小儿恶性黑色素瘤往往更深(>1 mm; OR=5.48; P = .002),有更

背景:儿童黑色素瘤可能会被误诊,因为它的稀有性和不典型的表现。

目的:试图探究儿童黑色素瘤与Breslow深度和临床行为的相关性,识别皮肤科医生和非皮肤科医生的误诊情况。

方法:对2000-2015年梅奥诊所诊断为原发性皮肤黑色素瘤的≤21岁患者进行回顾性研究。

结果:与临床表现为恶性黑色素瘤相比,模仿皮肤良性病变的小儿恶性黑色素瘤往往更深(>1 mm; OR=5.48; P = .002),有更高的T分期(OR[T2, T3, or T4] 6.28; P = .001)。小儿恶性黑色素瘤中,66%最初诊断为良性黑色素细胞病变,表现出大小、形状和颜色的变化。

局限:样本大小和回顾性设计是局限性。

结论:小儿皮肤病变出现出血、溃疡等变化时,应警惕黑色素瘤的可能。模仿皮肤良性病变的小儿恶性黑色素瘤往往Breslow更深,有更高的T分期。虽然儿童活检不太实用,但是仍需要安全、密切的监测。

原始出处:

Mitkov M,et al.Pediatric melanomas often mimic benign skin lesions: A retrospective study.J Am Acad Dermatol. 2016 Jul 15. pii: S0190-9622(16)30296-1. doi: 10.1016/j.jaad.2016.05.015. [Epub ahead of print]

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1680344, encodeId=898e16803449d, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Tue Nov 29 04:47:00 CST 2016, time=2016-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1651830, encodeId=a53e1651830cb, content=<a href='/topic/show?id=3a3e1e9504' target=_blank style='color:#2F92EE;'>#ACA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1795, encryptionId=3a3e1e9504, topicName=ACA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=843c24278901, createdName=lishizhe, createdTime=Tue Aug 30 21:47:00 CST 2016, time=2016-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=117015, encodeId=552f11e01550, content=文章深入探讨。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Sep 09 22:10:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558753, encodeId=d3931558e532f, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Tue Jul 26 12:47:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564762, encodeId=27d61564e6257, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Tue Jul 26 12:47:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585674, encodeId=eaf915856e4e7, content=<a href='/topic/show?id=e76840556f9' target=_blank style='color:#2F92EE;'>#回顾性研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40556, encryptionId=e76840556f9, topicName=回顾性研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=037917278808, createdName=jiyangfei, createdTime=Tue Jul 26 12:47:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94616, encodeId=3df494616a3, content=儿童的总是那么特殊, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jul 25 16:24:00 CST 2016, time=2016-07-25, status=1, ipAttribution=)]
    2016-11-29 sunylz
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    2016-08-30 lishizhe
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    2016-09-09 ylzr123

    文章深入探讨。

    0

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    2016-07-25 oo902

    儿童的总是那么特殊

    0

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