Nature综述：皮肤伤口愈合的细胞和分子机制

2024-04-03 BioMed科技 BioMed科技发表于威斯康星

特别强调了伤口炎症反应中的先天和适应性免疫细胞如何影响传统研究的伤口细胞谱系，包括角质形成细胞、成纤维细胞和内皮细胞，还包括一些较少研究的细胞谱系，如脂肪细胞、黑色素细胞和皮肤神经。最后，作者讨论了有

皮肤伤口愈合的细胞和分子机制伤口愈合是一个复杂的过程，包括许多不同组织和细胞谱系的协调作用。它需要细胞迁移、增殖、基质沉积和重塑，以及炎症和血管生成的紧密协调。小的皮肤伤口在几天内愈合，而较大的损伤，例如外伤、急性疾病或重大手术所导致的伤口可能需要几周才能愈合，通常留下会影响组织功能的纤维瘢痕。开发预防瘢痕形成和成功修复慢性伤口的治疗方法需要对驱动伤口愈合的细胞和分子机制有更充分的了解。 2024年3月25日，布里斯托大学的Paul Martin和Oscar A. Peña两人，在Nature Reviews Molecular Cell Biology期刊上发表了一篇名为：Cellular and molecular mechanisms of skin wound healing的综述文章。该综述讨论了从凝血形成到重新上皮化、血管生成和随后瘢痕沉积的不同愈合阶段的当前理解。重点介绍了不同细胞类型对皮肤修复的贡献，特别强调了伤口炎症反应中的先天和适应性免疫细胞如何影响传统研究的伤口细胞谱系，包括角质形成细胞、成纤维细胞和内皮细胞，还包括一些较少研究的细胞谱系，如脂肪细胞、黑色素细胞

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2024-04-18 ms5000001879177969 来自浙江省

#伤口愈合#

7 0
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2024-04-07 ms6000000013039699 来自河北省

非常收益，学习了，谢谢

10 0
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2024-04-03 梅斯管理员来自威斯康星

#瘢痕# #伤口愈合# #伤口# #慢性伤口#

20 0
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2024-04-03 ms3000001340106445 来自四川省

非常收受益#Nat#

19 0

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