Brit J Cancer：钙、镁摄入与食管癌风险的关系

2020-04-04 MedSci原创 MedSci原创

在对NIH-AARP饮食和健康研究的前瞻性队列进行回顾性分析的基础上，饮食中钙和镁摄入量与食道癌发生的风险密切相关。如果经过验证，这些发现可以指导高危人群的饮食改变。

食道癌是全球癌症相关死亡率和发病率的主要原因，通过饮食调整的风险降低是预防食道癌的一种附加策略。近日，肿瘤领域权威杂志British Journal of Cancer上发表了一篇研究文章，研究人员旨在评估钙和镁的摄入量与食道癌发生之间的关联。

研究人员对NIH-AARP饮食和健康研究的前瞻性队列进行了回顾性分析，并采用多变量Cox比例风险建模来估计总摄入量与总的以及根据组织学类型(食管鳞状细胞癌(OSCC)和腺癌(OAC)）食道癌之间的关联。研究人员进行了敏感性和分层分析。

在536359名受访者中，在650万人次每年的随访期间共出现1414例食道癌患者。与最低四分位数的受访者相比，增加膳食钙摄入量与调整后的OSCC风险降低32-41%相关(趋势p=0.01)。增加镁摄入量和OAC风险之间存在着正相关，但只存在于钙：镁摄入量比值较低的受访者中(趋势p=0.04)，并且与吸烟的状态有很大的交互作用。

由此可见，在对NIH-AARP饮食和健康研究的前瞻性队列进行回顾性分析的基础上，饮食中钙和镁摄入量与食道癌发生的风险密切相关。如果经过验证，这些发现可以指导高危人群的饮食改变。

原始出处：

Shailja C. Shah,et al.Associations between calcium and magnesium intake and the risk of incident oesophageal cancer: an analysis of the NIH-AARP Diet and Health Study prospective cohort.British Journal of Cancer.2020.https://www.nature.com/articles/s41416-020-0818-6

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2020-10-03 lovetcm

膳食#钙#摄入量与调整后的#食管癌#中的OSCC风险降低32-41%相关。增加#镁#摄入量和OAC风险之间存在着正相关，虽然关系不是特别显著，表明不同的元素对人体的影响是复杂的。

279 0
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2020-05-16 docwu2019

#癌风险#

38 0
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2020-07-28 limedical1974

#风险的关系#

42 0
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2020-04-07 rwh126

学习了

112 0
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2020-04-06 zhouqu_8

#食管#

32 0
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2020-04-04 1226a71am04(暂无昵称)

学习了

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