CLIN CHEM LAB MED:测量人唾液中α-dicarbonyl化合物?

2020-01-31 MedSci MedSci原创

已经在包括血浆和尿液的体液中检测到α.

已经在包括血浆和尿液的体液中检测到α-二羰基化合物(α-DCs),并且体内这类化合物的升高与多种慢性疾病的发展有关。 然而,尚不确定人类唾液中是否存在α-DCs,以及它们的存在与否可能与多种慢性疾病有关。

本研究建立了柱前衍生化HPLC-UV法,以4-(2,3-二甲基-6-喹啉基)-1,2-苯二胺(DQB)为衍生化试剂,测定人唾液中3-脱氧葡萄糖酮(3-DG)、乙二醛(GO)、甲基乙二醛(MGO)、二乙酰基(DA)和戊二酮-2,3-二酮(PD)。α-DCs的衍生很快,条件也很容易。 对该方法进行了评估,结果表明该方法适用于定量人唾液中的α-DC

15位健康受试者和232糖尿病T2DM)患者的唾液中对这些α-DC的测量中,我们发现糖尿病患者唾液中GOMGO的浓度显着高于健康受试者 据我们所知,这是首次确定唾液中α-DC的浓度并与T2DM有关。因此,该方法将有助于唾液α-DC水平的测量以及糖尿病早期筛查

原始出处:

Xin-Jie WangHong-Xia ZhangMeasurement of α-dicarbonyl compounds in human saliva by pre-column derivatization HPLC

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    2020-04-25 jeanqiuqiu
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    2020-02-02 一天没事干

    很好的学习机会

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