Am J Gastroenterol:加拿大小儿炎症性肠炎流行趋势

2017-04-24 zhangfan MedSci原创

加拿大是世界上儿童炎症性肠炎发病率最高的国家之一,近年来炎症性肠炎患病率显着增加,特别是0至5岁幼儿发病率增长较快

小儿炎症性肠炎(IBD)的发病率在世界范围内呈上升趋势。近日研究人员使用人口基础健康管理数据,以确定加拿大全国、各省小儿炎症性肠炎发病率及流行趋势。

研究人员统计了1999-2010年间,占加拿大总人口数79.2%的阿尔伯塔省、曼尼托巴省、新斯科舍省、安大略和魁北克5省的、16岁以下炎症性肠炎诊断情况。标准化发病率以每十万个孩子计算,年百分比变化(APC)的发病率,采用泊松回归分析确定。省级估计采用随机效应模型进行分析,并以此产生国家级估计。

研究发现,全加拿大共确诊5214起炎症性肠炎,其中3462起克罗恩病,1382起溃疡性结肠炎,279起其他类型。每十万儿童炎症性肠炎发病率为9.68%(95% CI 9.11至10.25),除新斯科舍发病率略高之外,全国发病率与各省发病率接近;研究期间年发病率变化百分比无显着变化(+2.06%, 95% CI -0.64%至 +4.76%);但0至5岁幼儿的年发病率变化百分比显着上升(+7.19%, 95% +2.82% 至+11.56%);2010年时,加拿大每十万儿童中,确诊炎症性肠炎38.25起,年发病率变化百分比增加4.56%。

研究认为,加拿大是世界上儿童炎症性肠炎发病率最高的国家之一,近年来炎症性肠炎患病率显着增加,特别是0至5岁幼儿发病率增长较快。

原文出处:

Eric I Benchimol et al. Trends in Epidemiology of Pediatric Inflammatory Bowel Disease in Canada: Distributed Network Analysis of Multiple Population-Based Provincial Health Administrative Databases. Am J Gastroenterol. 2017-4-18.

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    2017-10-12 许安
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    2017-04-26 飘飘爱

    很好

    0

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