速效霍乱疫苗可以抑制疫情爆发

2018-06-24 MedSci MedSci原创

霍乱是一种肠道感染,如果不进行治疗就会迅速死亡。这种疾病是由霍乱弧菌引起的,这种细菌占据了小肠,并产生可引发呕吐和腹泻,导致严重的脱水,每年全世界有21,000至143,000人死于霍乱

霍乱是一种肠道感染,如果不进行治疗就会迅速死亡。这种疾病是由霍乱弧菌引起的,这种细菌占据了小肠,并产生可引发呕吐和腹泻,导致严重的脱水,每年全世界有21,000143,000人死于霍乱。在追踪2010年海地爆发的霍乱弧菌菌株的遗传起源之后,Waldor及其同事意识到,自从现有霍乱疫苗使用以来,细菌在数十年中发生了显著的变化。为了寻找更为有效的方法,Waldor和他的同事发现了被称为HaitiV疫苗的独特能力:它几乎可以立即保护兔子免受导致霍乱的细菌的感染。转化医学所描述的这种效应表明,该疫苗将会有效遏制霍乱的快速蔓延。

兔子的实验表明,速效霍乱疫苗可在一天内开始防止致命疾病的发生。霍华德休斯医学研究所(HHMI)的研究人员Matthew Waldor称,这种速效疫苗能够提供的快速保护、能够在一天内控制霍乱疫情的蔓延。研究人员尚未在人们身上测试该疫苗,但布莱根妇女医院的微生物学家沃尔多尔对该疫苗持乐观态度:我们认为这将是一种非常好的疫苗,并且可以在单剂量后诱导免疫


原始出处:

https://www.europeanpharmaceuticalreview.com/news/76506/fast-acting-cholera-vaccine-could-curb-outbreaks/

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    2018-06-26 klivis