Diabetologia:血清脂联素可预测2型糖尿病患者的骨折风险?

2017-10-23 MedSci MedSci原创

已经有报道称血清脂联素可影响一般人群的骨折风险。虽然2型糖尿病与骨折风险增加有关,但血清脂联素是否预测2型糖尿病患者的骨折仍不确定。近日,国际杂志 《Diabetologia》上在线发表一项关于血清脂联素预测2型糖尿病患者的骨折风险的研究。本研究的目的是前瞻性研究2型糖尿病患者血清脂联素与骨折风险之间的关系。

已经有报道称血清脂联素可影响一般人群的骨折风险。虽然2型糖尿病与骨折风险增加有关,但血清脂联素是否预测2型糖尿病患者的骨折仍不确定。近日,国际杂志 《Diabetologia》上在线发表一项关于血清脂联素预测2型糖尿病患者的骨折风险的研究。本研究的目的是前瞻性研究2型糖尿病患者血清脂联素与骨折风险之间的关系。 在这项数据来自福冈糖尿病登记处的一项多中心前瞻性研究中,研究人员旨在调查现代治疗对糖尿病患者预后的影响。研究人员分析了4869例2型糖尿病患者(平均年龄65岁),其中包括1951名绝经后妇女(定义为自我报告的闭经≥1年)和2754名男性,中位数年龄为5.3岁。主要结果是任何部位骨折和主要骨质疏松性骨折(MOF)。 研究发现随访期间,682人次发生了骨折(任何部位),MOF共277人次。在LOGe -转化的血清脂联素1个SD增量的经年龄校正的骨折和MOF的HR(95%CI)在绝经妇女中为1.27(1.15,1.40)和1.35(1.17,1.55),在男性中为1.22(1.08,1.38)和1.40(1.15,1.71)。MOF超高血脂症血症(≥20μg/ ml)的HR(95%CI

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