Cell:人类胚胎干细胞成功克隆,下一步复制人类?

2013-05-18 钟欣 京华时报

  美国俄勒冈卫生与科学大学的一个研究小组15日在美国科学期刊《细胞》网络版上发表文章,宣布已使用“体细胞克隆技术”,向卵细胞内植入他人皮肤细胞的细胞核,首次成功制造了能够分化成各种组织的胚胎干细胞。   干细胞是一类具有自我复制能力的多潜能细胞,在一定条件下,它可以分化成多种功能细胞。人类胚胎干细胞能够演变成构成人体的大约200多种细胞中的任何一种。   美国俄勒冈卫生与科学大学和俄勒冈国家

  美国俄勒冈卫生与科学大学的一个研究小组15日在美国科学期刊《细胞》网络版上发表文章,宣布已使用“体细胞克隆技术”,向卵细胞内植入他人皮肤细胞的细胞核,首次成功制造了能够分化成各种组织的胚胎干细胞。

  干细胞是一类具有自我复制能力的多潜能细胞,在一定条件下,它可以分化成多种功能细胞。人类胚胎干细胞能够演变成构成人体的大约200多种细胞中的任何一种。

  美国俄勒冈卫生与科学大学和俄勒冈国家灵长类研究中心科学家15日表示,该技术使用的是未受精的卵子。

  据介绍,研究小组将122个卵细胞去除细胞核,植入了他人皮肤细胞的细胞核,结果有21个发育到了被称为“囊胚”的阶段。取该组织的一部分进行培养,然后其中共6个成为了胚胎干细胞。促使胚胎干细胞分化成心肌后,研究小组还确认了脉动。

  据了解,不再需要使用人类胚胎可以提高干细胞的应用尝试。在心脏病、帕金森病、严重脊髓损伤和其他人体受损疾病的治疗中,他们的成果可以用来替代受损细胞或被破坏的细胞。

  但是,这项成果可能也会再次引起人们对克隆人类,也就是复制与活着或已经死亡的个人基因相同的人类的担忧。

原始文献:

Xie W, Schultz MD, Lister R, Hou Z, Rajagopal N, Ray P, Whitaker JW, Tian S, Hawkins RD, Leung D, Yang H, Wang T, Lee AY, Swanson SA, Zhang J, Zhu Y, Kim A, Nery JR, Urich MA, Kuan S, Yen CA, Klugman S, Yu P, Suknuntha K, Propson NE, Chen H, Edsall LE, Wagner U, Li Y, Ye Z, Kulkarni A, Xuan Z, Chung WY, Chi NC, Antosiewicz-Bourget JE, Slukvin I, Stewart R, Zhang MQ, Wang W, Thomson JA, Ecker JR, Ren B.Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells. Cell. 2013 May 7. doi:pii: S0092-8674(13)00464-9.

  Gifford CA, Ziller MJ, Gu H, Trapnell C, Donaghey J, Tsankov A, Shalek AK, Kelley DR, Shishkin AA, Issner R, Zhang X, Coyne M, Fostel JL, Holmes L, Meldrim J, Guttman M, Epstein C, Park H, Kohlbacher O, Rinn J, Gnirke A, Lander ES, Bernstein BE, Meissner A.Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells. Cell. 2013 May 7. doi:pii: S0092-8674(13)00513-8.

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    2013-07-20 d830372
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    2014-01-19 维他命
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    2013-05-20 ailian1202
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