Emerg Microbes Infect:什么是研究人类对H7N9禽流感病毒易感性的试剂来源?

2018-09-22 ipsvirus 病毒学界

禽流感H7N9病毒是一个重要的公共卫生问题,由于它的高死亡率和引发未来大流行的潜力。

禽流感H7N9病毒是一个重要的公共卫生问题,由于它的高死亡率和引发未来大流行的潜力。

研究人员使用重组H7N9血凝素蛋白作为探针,研究了人类对H7N9病毒的易感性。在2016年流行季节的中国江苏省的32个病例的唾液标本和60例未感染的对照样本中,研究人员发现在H7N9感染和血凝素结合之间一个强的相关性。研究人员也发现被H7N9病毒识别的唾液酸Lex (SLex) 抗原也与该病毒感染有关。进一步分析表明,毗邻SLex的额外的糖残基可能影响H7N9病毒结合的特异性。

该实验数据表明,唾液可能是研究人类对H7N9病毒易感性的有用的试剂,这会影响对这种重要的人类病原引起疾病的预防和控制。


图1 功能性H7型病毒HA1蛋白的产生和验证


图2  唾液标本S60-HA1蛋白结合信号和H7N9感染之间的关联

原始出处:Tan M, Cui L, Huo X, et al. Saliva as a source of reagent to study human susceptibility to avian influenza H7N9 virus infection. Emerg Microbes Infect. 2018 Sep 19;7(1):156.

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    2019-01-02 xjy02
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