Heart:心血管疾病和心脏损伤对COVID-19患者住院死亡率的影响

2020-05-29 MedSci原创 MedSci原创

COVID-19患者具有潜在的心血管合并症,包括CVD和高血压,可能面临更大的致命危险。急性心脏损伤可能是死亡风险的标志。鉴于该荟萃分析未经调整的结果,有必要进行进一步的研究。

冠状病毒病2019(COVID-19)在全球范围内已经产生了巨大的健康负担,尤其是在伴有心血管疾病的患者中。近日,心脏病领域权威杂志Heart上发表了一篇研究文章,该系统评价和荟萃分析的目的是评估潜在的心血管合并症和急性心脏损伤对医院内死亡风险的影响。

研究人员检索了PubMed、Embase和Web of Science数据库,以查找报道COVID-19患者潜在心血管疾病(CVD)、高血压和心肌损伤与院内致命结局之间关系的文献。研究人员提取数据或合并OR,并进行亚组和敏感性分析以探索异质性的潜在来源。

该荟萃分析共纳入了10项研究,包含8项CVD研究,7项高血压研究,以及8项急性心脏损伤研究。CVD和高血压的存在与院内死亡率的增加相关(未调整的OR为4.85,95%CI为3.07至7.70; I2=29%;未调整的OR为3.67,95%CI为2.31至5.83;I2=57%)。急性心脏损伤也相关,并伴有较高的未调整几率为21.15(95%CI为10.19至43.94;I2=71%)。

由此可见,COVID-19患者具有潜在的心血管合并症,包括CVD和高血压,可能面临更大的致命危险。急性心脏损伤可能是死亡风险的标志。鉴于该荟萃分析未经调整的结果,有必要进行进一步的研究。

原始出处:

Xintao Li.et al.Impact of cardiovascular disease and cardiac injury on in-hospital mortality in patients with COVID-19: a systematic review and meta-analysis.heart.2020.https://heart.bmj.com/content/early/2020/05/26/heartjnl-2020-317062

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    2020-05-30 zhaojie88
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    2020-05-30 slcumt

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