Neurology:血浆中支链氨基酸与肌萎缩侧索硬化症风险

2018-11-16 zhangfan MedSci原创

研究认为,血浆中支链氨基酸含量与肌萎缩侧索硬化症风险无关

近日研究人员考察了诊断前血浆支链氨基酸(BCAA)水平与肌萎缩侧索硬化症(ALS)之间的关系。

研究人员考察了5个队列研究,总计275名后续确诊ALS患者的相关资料,通过LC-MS测定代谢物含量,采用逻辑回归法评估个体BCAA与ALS危险的相关性。

研究发现,考察的3种BCAA与ALS风险升高不相关,血浆亮氨酸、异亮氨酸以及缬氨酸含量最高人群与最低人群ALS风险比值比分别为0.87、0.81以及0.80,其结果在调整了体重、吸烟、教育水平以及体育活动等因素后保持,且不受性别、禁食以及发病状态的影响。

研究认为,血浆中支链氨基酸含量与肌萎缩侧索硬化症风险无关。

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    2019-01-18 chendoc252
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    2019-09-13 yinhl1978
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    2018-11-17 坚强007

    向ALS科研者致敬!!!

    0

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