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Adv Sci：适应性水凝胶可有效增强组织再生

2018-12-26 MedSci MedSci原创

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通过同一载体有针对性地同时递送性质不同的各种货物是非常有吸引力且具有挑战性的。本研究描述了基于透明质酸和自组装帕米膦酸镁纳米颗粒的生物活性纳米复合水凝胶，用于局部洗脱和按需同时释放生物活性离子和小分子药物。结果系那是，所制备的纳米复合水凝胶具有优异的注射性和有效的应力松弛，从而允许容易注射并随后使水凝胶适应具有不规则形状的骨缺陷。从水凝胶释放的镁离子促进包封的人间充质干细胞（hMSCs）的成骨分化

通过同一载体有针对性地同时递送性质不同的各种货物是非常有吸引力且具有挑战性的。本研究描述了基于透明质酸和自组装帕米膦酸镁纳米颗粒的生物活性纳米复合水凝胶，用于局部洗脱和按需同时释放生物活性离子和小分子药物。

结果系那是，所制备的纳米复合水凝胶具有优异的注射性和有效的应力松弛，从而允许容易注射并随后使水凝胶适应具有不规则形状的骨缺陷。从水凝胶释放的镁离子促进包封的人间充质干细胞（hMSCs）的成骨分化和碱性磷酸酶（ALP）的活化。活化的ALP随后催化Dex磷酸盐（Dex的前药）的去磷酸化（活化），并加速Dex从水凝胶中的释放，以进一步促进hMSCs成骨。这种控制Dex活化和释放的正反馈电路显著增强了水凝胶植入部位的骨再生。

综上所述，该研究结果表明，这些可注射的纳米复合水凝胶介导了各种治疗药物的优化释放，并通过微创手术有效促进原位骨再生。

原始出处：

Zhang K, Jia Z, et al., Adaptable Hydrogels Mediate Cofactor-Assisted Activation of Biomarker-Responsive Drug Delivery via Positive Feedback for Enhanced Tissue Regeneration. Adv Sci (Weinh). 2018 Oct 22;5(12):1800875. doi: 10.1002/advs.201800875. eCollection 2018 Dec.

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    2018-12-28 tastas

    #水凝胶#

    0

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    2018-12-28 lishizhe

    #凝胶#

    0

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    2018-12-28 sunyl13

    #组织再生#

    0

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    2018-12-28 huhuaidong394

    #适应性#

    0

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    2018-12-27 1391f90535m

    厉害

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1308034, encodeId=485a130803481, content=<a href='/topic/show?id=edd364149bc' target=_blank style='color:#2F92EE;'>#水凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64149, encryptionId=edd364149bc, topicName=水凝胶)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Fri Dec 28 03:34:00 CST 2018, time=2018-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460994, encodeId=9b64146099489, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Fri Dec 28 03:34:00 CST 2018, time=2018-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591995, encodeId=f3511591995c1, content=<a href='/topic/show?id=595ce765983' target=_blank style='color:#2F92EE;'>#组织再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77659, encryptionId=595ce765983, topicName=组织再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e818060478, createdName=sunyl13, createdTime=Fri Dec 28 03:34:00 CST 2018, time=2018-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621020, encodeId=1f5a162102014, content=<a href='/topic/show?id=dccc94e01c9' target=_blank style='color:#2F92EE;'>#适应性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94701, encryptionId=dccc94e01c9, topicName=适应性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b13a20191510, createdName=huhuaidong394, createdTime=Fri Dec 28 03:34:00 CST 2018, time=2018-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356559, encodeId=831d35655966, content=厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/10/2f6c850029fe76c49f0360e0533a1be6.jpg, createdBy=04d12112875, createdName=1391f90535m, createdTime=Thu Dec 27 22:40:19 CST 2018, time=2018-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356468, encodeId=88603564685b, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Wed Dec 26 13:55:01 CST 2018, time=2018-12-26, status=1, ipAttribution=)]
    2018-12-26 王秀

    学习了，涨知识了！

    0