Nature Chemistry:新型荧光肺结核检测方法简单易行

2012-09-04 黄堃 新华社

  英国《自然—化学》杂志9月2日刊登论文说,美国研究人员开发出一种简单易行的新型肺结核检测方法,只需在检测装置中加入痰液,若含有结核杆菌,检测装置就会发出荧光。有需要的人可在家自行检测。   肺结核由结核杆菌引起,传染性很强。如果怀疑有感染迹象,及时检查很重要,但过去的一些检测方法耗时较长,且需要专门的仪器设备和人员。   美国斯坦福大学等机构研究人员报告

 
英国《自然—化学》杂志9月2日刊登论文说,美国研究人员开发出一种简单易行的新型肺结核检测方法,只需在检测装置中加入痰液,若含有结核杆菌,检测装置就会发出荧光。有需要的人可在家自行检测。
 
肺结核由结核杆菌引起,传染性很强。如果怀疑有感染迹象,及时检查很重要,但过去的一些检测方法耗时较长,且需要专门的仪器设备和人员。
 
美国斯坦福大学等机构研究人员报告说,结核杆菌会分泌一种名为BlaC的酶,据此设计出一种能与这种酶反应的分子,两者反应后会发出荧光。在此基础上制成的检测装置只需在其中加入痰液,若含有结核杆菌,检测装置就会发出荧光。如果自行检测者拿不准如何判断荧光,可用手机拍照后传给专业医生,无须亲自到医院就能获知检测结果。
 
这种新型检测方法灵敏度很高,样本中只含少量的结核杆菌就能检测出来。与之相比,传统的利用显微镜观察样本中是否含结核杆菌的方法,在结核杆菌数量很少时常常判断困难。
 
过去也有类似探索,但所用分子不只对结核杆菌敏感,也会引起其他一些种类的细菌产生反应。本次研究针对这一问题进行改进,所用分子只有遇到结核杆菌分泌的酶时才发出荧光。
 
据介绍,研究人员正在开发这种检测装置的商业化生产,预计相关产品几年内就能上市。
 
 
链接:Hexin Xie,1, 5 Joseph Mire,2, 5 Ying Kong,3, 5 MiHee Chang,3 Hany A. Hassounah,3 Chris N. Thornton,4 James C. Sacchettini,2 Jeffrey D. Cirillo3 & Jianghong Rao1.Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic probe.Nature Chemistry,2012
 
 

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    2013-07-28 liye789132251
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