Eur Radiol:基于T2加权脂肪抑制和扩散加权 MRI的放射学分析在术前预测乳腺癌前哨淋巴结转移的价值

2017-08-26 shaosai MedSci原创

前哨淋巴结是原发肿瘤引流区域淋巴结中的特殊淋巴结,是原发肿瘤发生淋巴结转移所必经的第一批淋巴结。前哨淋巴结作为阻止肿瘤细胞从淋巴道扩散的屏障,其临床意义已受到人们的重视。本研究旨在预测基于T2加权脂肪抑制(T 2-FS)和扩散加权 MRI(DWI)的放射学分析在术前预测乳腺癌前哨淋巴结(SLN)转移的价值,并将结果发表在Eur Radiol上。

前哨淋巴结是原发肿瘤引流区域淋巴结中的特殊淋巴结,是原发肿瘤发生淋巴结转移所必经的第一批淋巴结。前哨淋巴结作为阻止肿瘤细胞从淋巴道扩散的屏障,其临床意义已受到人们的重视。本研究旨在预测基于T2加权脂肪抑制(T 2-FS)和扩散加权 MRI(DWI)的放射学分析在术前预测乳腺癌前哨淋巴结(SLN)转移的价值,并将结果发表在Eur Radiol上。

本研究共纳入了146例经组织病理学证实为乳腺癌的患者,并在治疗前行T2-FS和DWI MRI检查。总体上,从每位患者中获取共有10962种纹理分析和4种非纹理特点。采用0.623+自助引导法和曲线下面积(AUC)来选择特征变量。基于不同的图像特征组合利用前进法建立10 级Logisti回归模型(1-10)。

对于T2-FS序列,包含10种特征的模型10具有最高的曲线下面积0.847(在训练组)和0.770(在确认组)。对于DWI,包含8种特征的模型8具有最高的AUC0.847(在训练组)和0.787(在确认组)。当联合T2-FS和DWI两种序列,包含10中特征的模型10具有最高的AUC 0.863(在训练组)和0.805(在确认组)。

本研究表明,从解剖学和功能MRI图像中提取的乳腺癌特征性的纹理标准有助于提高放射组预测SLN转移的能力,从而成为一种临床上非侵入性的方法。

原始出处:


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    2017-08-30 大爰

    学习了谢谢分享

    0

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    2017-08-30 大爰

    学习了谢谢分享!!

    0

  3. 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    2017-08-29 lou.minghong

    学习谢谢分享!

    0

  4. 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  5. 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  6. 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    2017-08-28 kkunny
  7. 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  8. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Aug 27 09:10:57 CST 2017, time=2017-08-27, status=1, ipAttribution=)]
    2017-08-28 sodoo
  9. 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    2017-08-27 天涯183

    非常好的文章.学习了.很受益

    0

  10. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Aug 27 09:10:57 CST 2017, time=2017-08-27, status=1, ipAttribution=)]
    2017-08-27 Y—xianghai

    学习了新知识

    0

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Environmental Health Perspectives:光明下的肿瘤帮凶:夜间光照暴露增加患乳腺癌风险?

随着科技和生活的进步,越来越多的人生活在霓虹灯下的“不夜城”。可你是否会想到光照竟是恶性肿瘤的无形帮凶?可见光,顾名思义,是电磁波谱中人眼可以感知的部分,故而并不包括X光或其他损伤皮肤的紫外线。传统意义上,有害物质是剂量相关的:少而致伤,多可致毒。而可见光暴露的毒性无疑挑战着我们对于有毒物质的传统定义。可见光对人体健康的损害极其依赖于暴露的发生时间、而非所有的累积时间长度。百万年来,人类已经进化形

JNCI:早期乳腺癌延长AI辅助治疗与哪些副反应呈正相关?

目前,已经有多个随机对照临床研究报道,在辅助5年内分泌治疗的基础上,进一步延长内分泌治疗的时长,可以改善患者的预后。但延长的AI辅助治疗,会不会增加毒副作用,目前尚未明确。近期,《JNCI》杂志发表了最新荟萃分析,纳入7个随机临床研究16349例患者,评估延长AI辅助治疗对患者心血管不良事件、骨折风险、其他部位第二原发癌、因不良事件中止治疗和复发前死亡的影响。背景绝经后早期乳腺癌患者术后辅助芳

CLIN CANCER RES:乳腺癌新辅助化疗过程中的转录反应

化疗导致的基因表达改变是由于肿瘤细胞转录重编或对于治疗的亚克隆适应。CLIN CANCER RES近期发表了一篇文章,研究对全转录组mRNA表达的影响,评估新辅助化疗联合贝伐单抗的治疗效果。

湖南一乳腺癌患者偏方“自救”,肿瘤变成皮球大小才去医院

8月24日,岳阳市中医院,36岁的谢雨梦躺在病床上,等待着切片结果。右侧乳房上巨大的肿瘤成了她的噩梦。近一年半的时间,肿瘤从花生米大小变成皮球大小,甚至溃烂、发臭、长蛆。她寻求过多种方法自救——服用偏方、吃“素食”,甚至被人使用放血疗法。唯一没做的,就是去正规医院治疗。直到奄奄一息,她才同意去医院寻求手术治疗。医生给她的答复是:来晚了。自救偏方、素食,成为她寻求治愈的方法事实上,从2016年3