J Gastroenterology: 消瘦个体的胰周脂肪与2型糖尿病发生率的相关性

2020-04-04 MedSci原创 MedSci原创

目前只有少数研究纵向评估了胰腺周围脂肪增多是否会增加2型糖尿病(T2D)的患病风险,但其结果并不一致。胰周脂肪与超重和肥胖密切相关,但以前的研究并未排除超重或肥胖的个体。

背景:目前只有少数研究纵向评估了胰腺周围脂肪增多是否会增加2型糖尿病(T2D)的患病风险,但其结果并不一致。胰周脂肪与超重和肥胖密切相关,但以前的研究并未排除超重或肥胖的个体。因此,这项队列研究旨在调查了瘦人中脂肪胰腺与T2D发生率之间的关系。

方法:在2008年至2013年之间,研究人员对1478名非糖尿病瘦子(即身体质量指数<25 kg / m 2)进行了健康检查(计算机断层扫描(CT)),平均随访时间为6.19年。脂肪胰腺通过组织学验证的方法在基线时使用CT上的胰腺衰减(Hounsfield单位[HU])进行评估;较低的胰腺衰减表明更多的胰腺脂肪。为了检测T2D事件,研究人员使用了空腹血浆葡萄糖,HbA1c以及处方抗糖尿病药物的自我报告。

结果:在随访期间有61名参与者(4.13%)出现了T2D的发病。基线时较低的胰腺衰减(即更多的胰腺脂肪)与T2D发生相关(OR:1.56 [95%CI 1.28-1.91],p<0.001)。经多变量调整的分析显示出相似的关联(OR:1.32 [95%CI 1.06-1.63],p= 0.012)。 结论 T2D可能在患有胰腺周围脂肪增多的瘦人中出现。 

原始出处:

Hajime Yamazaki. Et al. Longitudinal association of fatty pancreas with the incidence of type-2 diabetes in lean individuals: a 6-year computed tomography-based cohort study. J Gastroenterology.2020.

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    2021-01-11 fengyqf
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    2021-01-09 许安
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    2020-04-05 misszhang

    谢谢MedSci提供最新的资讯

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新冠肺炎疫情在中国已经得到了有效防控,但在其他许多国家正呈现迅猛的爆发趋势,医疗资源的短缺问题迫在眉睫。病毒的彻底清除是衡量新冠患者痊愈的金标准。那么患者体内病毒清除平均需要多长时间?

Medicine (Baltimore):轻度蛋白尿与听力损失有关

在非糖尿病人群中,高水平的蛋白尿与听力损失有关,而轻度蛋白尿额临床影响很少有关注。最近,有研究人员进行了基于群体的代表性研究调查了在美国非糖尿病男性中,是否听力损失与轻度蛋白尿或者肾小球过滤(eGFR

JACC:接受PCI的高危糖尿病患者采用替卡格雷治疗加或不加阿司匹林疗效比较

与替卡格雷加阿司匹林相比,替卡格雷单药治疗降低临床相关出血风险而不增加缺血性事件的功效在接受PCI的糖尿病患者和非糖尿病患者中是一致的。

Nature Food: 精制淀粉和糖要为全球肥胖和糖尿病负责!

近期,Nature子刊一篇文章指出,要解决目前肥胖和2型糖尿病流行,要从食物入手,应当吃具有生物活性的食物,例如水果、坚果、种子、非淀粉类蔬菜、豆类、植物油、全谷物、酸奶和鱼,而少吃加工食物。

Nat Bio Eng:一项新技术能在体内产生胰岛素,治疗糖尿病

导言:糖尿病是一组因胰岛素绝对或相对分泌不足(或)胰岛素利用障碍引起的碳水化合物、蛋白质、脂肪代谢紊乱性疾病,以高血糖为主要标志。目前尚无根治糖尿病的方法,但通过多种治疗手段可以控制好糖尿病,主要包括

J Periodon Res:晚期糖基化终末产物增加人口腔上皮细胞脂钙蛋白2的表达

糖尿病(DM)是牙周病的危险因素,会加重牙周病的严重程度。 糖尿病并发症的主要因素之一是晚期糖基化终末产物(AGEs)在牙周组织中积累并引起炎症反应。