29岁孕妇查出宫颈癌晚期,上海医生多学科配合救回母婴二人

2017-07-04 陈斯斯 澎湃新闻

怀上了孩子,却被查出宫颈癌晚期。29岁的杨晓娟(化名)和她的孩子在上海市第一妇婴保健院被救了回来。7月3日,记者从院方获悉,杨晓娟在孕32周时成功分娩,诞下2086克的新生儿,紧接着,医生对她进行了宫颈癌根治术。目前,母婴均已脱离生命危险,恢复出院。怀孕的欣喜让杨晓娟忽略了初诊结果。据医院介绍,在患者杨晓娟怀孕初诊的检查结果里,有一项是“宫颈涂片异常”。她来到医院妇科、宫颈科相关门诊,医生建议进行

怀上了孩子,却被查出宫颈癌晚期。

29岁的杨晓娟(化名)和她的孩子在上海市第一妇婴保健院被救了回来。7月3日,记者从院方获悉,杨晓娟在孕32周时成功分娩,诞下2086克的新生儿,紧接着,医生对她进行了宫颈癌根治术。目前,母婴均已脱离生命危险,恢复出院。

怀孕的欣喜让杨晓娟忽略了初诊结果。

据医院介绍,在患者杨晓娟怀孕初诊的检查结果里,有一项是“宫颈涂片异常”。她来到医院妇科、宫颈科相关门诊,医生建议进行宫颈组织活检,以进一步排查。然而,她担心宫颈活检造成流产,明确拒绝了医生的建议。

过了一段时间,杨晓娟出现阴道流液,被收住入院。经过一些列检查后,产科医生认为阴道流液并非胎膜早破,再次建议她进行宫颈活检。经过医生反复劝说,她在两周后同意进行活检。经病理活检,杨晓娟被确诊罹患宫颈浸润性鳞状细胞癌,而且已经到了ⅡA2期的阶段。

继续妊娠还是终止妊娠?

如果直接放弃妊娠,切除子宫后,杨晓娟将永久性地丧失生育功能,永远失去做母亲的机会;如果立刻分娩并进行切除手术,6月龄的胎儿,多器官未发育成熟,不仅早产风险大,而且存活率低。

面对杨晓娟强烈的继续妊娠的愿望,由院长万小平、产科主任应豪、新生儿科主任刘江勤等专家带领的多学科诊治小组,考虑到患者病症情况、妊娠阶段、胎儿早产风险等因素,反复查阅资料、细致斟酌、调整治疗及分娩方案,制定出了适合她病情和胎儿发育的治疗方案。

从被检查出妊娠合并宫颈癌到成功分娩,有7周的时间,这段时间对杨晓娟而言无比漫长。她一度产生焦虑、抑郁的倾向,经过医护人员疏导安慰,在人性化、精细化的治疗方案推进下,杨晓娟的不良情绪也得到有效缓解。

按照治疗方案,杨晓娟在孕28周后开始接受一期化疗。

对于化疗可能给胎儿带来的影响,该院多名专家指出,查阅文献发现,目前美国对于妊娠期患宫颈癌、肝癌等需要化疗药物治疗的孕妇登记与跟踪结果来看,与不需要用化疗药物的健康人群相比,孕早期化疗对胎儿存在一定影响,孕中晚期因胎儿已经发育到一定阶段,从目前已有随访资料来看,化疗对出生后发育、智力等影响并不明显。

妊娠至32周时,结合病情和杨晓娟意愿,医生应豪主刀,成功地对她进行剖宫产,宝宝出生评分非常高;紧接着,医生万小平主刀,给杨晓娟进行了宫颈癌根治术。

术后第4天,杨晓娟迫不及待地走进新生儿重症监护病房,面对眼前这份来之不易的小生命,她含泪露出了笑颜。

据医院透露,杨晓娟分娩后,新生儿经过数10天的呼吸支持,在新生儿科进一步治疗、监护下,闯过早产儿成长的风险难关,经过一个多月的治疗、喂养,目前已经顺利出院。

专家团队表示,杨晓娟罹患的宫颈癌,属于局部晚期阶段,尽快进行宫颈癌根治术是最佳的治疗方案。目前公认的妊娠期宫颈癌的治疗目标是,健康足月成熟儿、控制疾病和保留生育能力。诊断时,如果胎肺已成熟,或是已经到达或接近预产期,最佳方案是立即终止妊娠,并且对患者进行必要的治疗。如果预判新生儿存活率低,而患者又决定放弃妊娠,则立即对患者进行治疗。对于其他患者,必须根据疾病的分期、诊断时妊娠孕周、以及患者及家属对于妊娠的想法,对分娩及治疗的时机进行仔细评估。

孕期做“宫颈刮片”是否真如上述孕妇所担忧的,会造成流产?

该院妇科主任郭晓青表示,怀孕之后,首先孕妇应该在怀孕12周-16周进行宫颈癌筛查。宫颈癌筛查一般先做细胞学检查,也就是俗称的“宫颈刮片”。“有些妈妈们可能会担心刮片后发生宫颈出血,引发流产,但其实现在的宫颈刮片已经很少用以前木质或是竹制的刮片了,取而代之的是柔软的毛刷,即使有少量阴道流血,也不会增加流产的几率,对于宝宝是绝对安全的。”郭晓青说。

专家介绍,由于近年来人们生活习惯的改变,中国宫颈癌年轻化趋势越来越明显,1/3的宫颈癌发生在生育年龄女性,而一旦在怀孕的时候或是产后6个月内查出宫颈癌,就称作妊娠合并宫颈癌或是妊娠相关性宫颈癌,在每1000-5000名孕妇中,就有1人可能会合并宫颈癌。

然而,怀孕期间的宫颈癌常常会被孕妇忽视,“一是由于许多人传统的观念认为,怀孕期间是不能随便做妇科检查的,尤其是在宫颈上做检查,因此在怀孕加上哺乳期的接近两年的时间里就拒绝做常规妇科检查,从而失去了早期诊断的机会;二是由于即使是怀孕期间出现了不规则阴道流血或是白带异常的症状,大家首先容易想到的是流产、早产、或是阴道炎,而很少会想到宫颈癌的可能性。”郭晓青表示。

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    2017-07-08 大爰

    学习并分享!!

    0

  3. 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    2017-07-07 flysky120

    孕妇得癌症,治疗方案困难危险性高

    0

  4. 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    2017-07-06 heli0118
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    2017-07-06 zhouqu_8
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06:39:35 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218630, encodeId=b0012186306b, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Wed Jul 05 00:29:01 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218626, encodeId=2ceb21862692, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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  7. 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06:39:35 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218630, encodeId=b0012186306b, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Wed Jul 05 00:29:01 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218626, encodeId=2ceb21862692, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2017-07-06 ylzr123

    认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦

    0

  8. 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06:39:35 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218630, encodeId=b0012186306b, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Wed Jul 05 00:29:01 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218626, encodeId=2ceb21862692, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Jul 05 00:08:41 CST 2017, time=2017-07-05, status=1, ipAttribution=)]
    2017-07-05 189****7206

    学习了谢谢分享

    0

  9. 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06:39:35 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218630, encodeId=b0012186306b, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Wed Jul 05 00:29:01 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218626, encodeId=2ceb21862692, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Jul 05 00:08:41 CST 2017, time=2017-07-05, status=1, ipAttribution=)]
    2017-07-05 飛歌

    厉害了我的哥

    0

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这是一年前遇到的故事,完稿时治疗还未结束,因此文章在后台存放至今。现在,另一只鞋子终于落下,这个故事也可以讲了。

HPV高危型阳性是否等于宫颈癌,无癌前病变不影响顺产

宫颈癌在全世界范围内发病率仅次于乳腺癌,居女性恶性肿瘤第二位,而在发展中国家则居首位。数据显示,中国是世界上宫颈癌发病率和死亡率最高的国家之一。35%的中国女性患有宫颈疾病,每年新增恶性宫颈病变人数达13.15万,约占世界宫颈癌患者总数的28.8%。世界卫生组织(WHO)数据显示,中国女性终身患宫颈癌的风险大约为0.9%,并且有上升和年轻化的趋势。自从德国科学家、诺贝尔医学奖得主哈拉尔德·楚尔

Int J Gynecol Cancer:淋巴结阳性的早期子宫颈癌的治疗

简介:不同医疗机构,对于术中发现淋巴结阳性的早期宫颈癌患者实施子宫切除术的管理有所不同。该研究目的是比较接受子宫切除术后继续接受放疗以及不接受手术直接放化疗患者的存活率和毒副反应。

Sci Rep:李静课题组阐明海洋来源抗霉素类化合物有望抗宫颈癌

近期,Nature旗下学术期刊Scientific Reports在线发表了中国海洋大学医药学院李静课题组和顾谦群课题组关于海洋天然产物抗宫颈癌的最新研究论文 Marine Streptomyces sp. Derived antimycin analogues suppress HeLa cells via depletion HPV E6/E7 mediated by ROS-dependen

Obstet Gyneco:多学科讨论 2009年指南更新后宫颈癌筛查过度与不足加剧

因宫颈癌的普遍筛查和治疗死亡率显著降低,但研究表明过度筛查包括操作带来的并发症、假阳性结果的治疗等也造成了伤害。2017年1月,发表在《Obstet Gynecol》的一项研究调查了宾西法尼亚Medicaid中2009年美国妇产科医生协会指南公布前后宫颈癌筛查的变化。研究结果显示,指南变更后宫颈癌过度筛查和过低筛查率均较高。请看本期多学科讨论组临床药师各抒己见为您梳理本文看点——目的:评估2009

JCO:子宫颈上皮内瘤变Ⅲ级者,其它部位的HPV相关肿瘤风险长期持续增加

子宫颈上皮内瘤变(cervical intraepithelial neoplasia CIN):将子宫颈上皮非典型增生至原位癌这一系列癌前病变的连续过程称为子宫颈上皮内瘤变。根据细胞改变程度和异型细胞范围可将CIN分为三级:Ⅰ级为轻度不典型增生,不典型细胞局限于上皮下1/3;Ⅱ级为中度不典型增生,不典型细胞主要位于上皮下1/3~2/3层,细胞极性尚存;Ⅲ级为重度不典型增生和(或)原位癌,病变细胞