Microvasc Res:健康和糖尿病视网膜病变受试者中结膜微血管血流动力学测量的时间变化!

2018-02-15 cuiguizhong MedSci原创

美国加利福尼亚州南加州大学眼科学系的Khansari MM近日在Microvasc Res杂志上发表了一项重要工作。结膜微循环成像是一种非侵入性技术,可以用于检测由全身和眼部疾病引起的血液动力学变化。然而,由于疾病发展引起的血流动力学变化监测需要纵向检测,即记录随时间变化的测量。本研究的目的是确定非糖尿病对照组(NC,N = 7)和糖尿病视网膜病变(DR,N = 10)受试者中结膜微血管血流动力学

美国加利福尼亚州南加州大学眼科学系的Khansari MM近日在Microvasc Res杂志上发表了一项重要工作。结膜微循环成像是一种非侵入性技术,可以用于检测由全身和眼部疾病引起的血液动力学变化。然而,由于疾病发展引起的血流动力学变化监测需要纵向检测,即记录随时间变化的测量。本研究的目的是确定非糖尿病对照组(NC,N = 7)和糖尿病视网膜病变(DR,N = 10)受试者中结膜微血管血流动力学在随访期间的变化。

在2次访视期间进行了结膜微血管成像,间隔时间为17±12周。分析图像来确定血管直径(D)、轴向血流速度(V)、血流量(Q)、壁剪切速率(WSR)和壁剪切应力(WSS)。随访期间的差异是根据平均访问间差异确定的。

分析发现,在非糖尿病对照组(NC)中,血管直径(D)、轴向血流速度(V)、血流量(Q)、壁剪切速率(WSR)和壁剪切应力(WSS)的随访调查差异分别为0.2±0.5μm、-0.01±0.16mm / s、-8±46pl / s、-3±46s-1和-0.01± 0.10dyne / cm2。 在糖尿病视网膜病变(DR)组中, 95%置信区间中,血管直径(D)、轴向血流速度(V)、血流量(Q)、壁剪切速率(WSR)和壁剪切应力(WSS)的随访间差异分别超过对照组60%,20%,40%,20%和20%。

因此,他们认为,随着时间的推移,在非糖尿病受试者中建立了血流动力学的纵向测量。同时作者认为,该方法具有检测糖尿病视网膜病变发展引起的纵向变化的潜力。

原文出处:

Khansari, M.M., et al., Inter-visit variability of conjunctival microvascular hemodynamic measurements in healthy and diabetic retinopathy subjects. Microvasc Res, 2018. 118: p. 7-11.

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  5. 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createdAvatar=, createdBy=669d219, createdName=mgqwxj, createdTime=Sat Feb 17 00:03:00 CST 2018, time=2018-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392012, encodeId=60a013920124a, content=<a href='/topic/show?id=3704891621c' target=_blank style='color:#2F92EE;'>#血流动力学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89162, encryptionId=3704891621c, topicName=血流动力学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99cf2500102, createdName=zjshifan_98647306, createdTime=Sat Feb 17 00:03:00 CST 2018, time=2018-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413932, encodeId=98df141393296, content=<a href='/topic/show?id=27b290e82f4' target=_blank style='color:#2F92EE;'>#视网膜病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90782, encryptionId=27b290e82f4, topicName=视网膜病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7143034078, createdName=zhanfl, createdTime=Sat Feb 17 00:03:00 CST 2018, time=2018-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446090, encodeId=778614460902f, content=<a href='/topic/show?id=23f4380e5f9' target=_blank style='color:#2F92EE;'>#受试者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38075, encryptionId=23f4380e5f9, topicName=受试者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24035191312, createdName=xinmeili, createdTime=Sat Feb 17 00:03:00 CST 2018, time=2018-02-17, status=1, ipAttribution=)]
    2018-08-16 xjy02
  6. 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topicList=[TopicDto(id=90782, encryptionId=27b290e82f4, topicName=视网膜病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7143034078, createdName=zhanfl, createdTime=Sat Feb 17 00:03:00 CST 2018, time=2018-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446090, encodeId=778614460902f, content=<a href='/topic/show?id=23f4380e5f9' target=_blank style='color:#2F92EE;'>#受试者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38075, encryptionId=23f4380e5f9, topicName=受试者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24035191312, createdName=xinmeili, createdTime=Sat Feb 17 00:03:00 CST 2018, time=2018-02-17, status=1, ipAttribution=)]
    2018-02-17 zutt
  7. 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    2018-02-17 mgqwxj
  8. 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  9. 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  10. 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