Lancet Infect Dis:全球非伤寒性沙门氏菌侵袭性疾病风险评估

2019-09-25 MedSci MedSci原创

研究发现,儿童、老年人和HIV感染者非伤寒性沙门氏菌侵袭性疾病风险较高

非伤寒性沙门氏菌侵袭性疾病是全球发病率和死亡率的主要原因。营养不良的儿童、最近患疟疾或镰状细胞贫血的儿童以及感染艾滋病毒的成年人患疾病风险较高。近日研究人员利用2017年全球疾病负担、伤害和危险因素研究(GBD)估算非伤寒性沙门氏菌侵袭性疾病负担。

研究人员对相关文献进行系统的审查,并利用贝叶斯元回归工具DisMod-MR,按年龄、性别和地理位置估算了1990年至2017年非伤寒性沙门氏菌的发病率和死亡率。研究人员按年龄、艾滋病毒状况和社会人口发展指数估计了病例死亡率。研究人员还计算了艾滋病毒可归因率和健康指标差距,包括残疾调整寿命(DALYs)。

研究人员估计2017年发生了53.5万例非伤寒沙门氏菌侵入性疾病,其中撒哈拉以南非洲发病率最高(34.5例/10万人-年),5岁以下儿童发病率最高(34.3例/10万人-年)。2017年估计有77 500人死亡,其中18 400人死于艾滋病毒,其余59 100人死于艾滋病以外因素。平均所有年龄病例死亡率为14.5%,其中5岁以下儿童(13.5%])和老年人(51.2%,在≥70岁的人群中)、艾滋病毒感染者(41.8%)和社会人口发展水平低的地区(如撒哈拉以南非洲地区为15.8%)的死亡率较高。

研究发现,儿童、老年人和HIV感染者非伤寒性沙门氏菌侵袭性疾病风险较高。

原始出处:

GBD 2017 Non-Typhoidal Salmonella Invasive Disease Collaborators.The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017.Lancet Infect Dis. September 24 2019.

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    2019-11-23 howi
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    2019-09-27 sunyl07
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