Cancer Epide Bio Prev:口腔致癌HPV可通过口-生殖器传播

2015-01-29 MedSci MedSci原创

据研究报道,对于其女性伴侣存在口腔或生殖器HPV感染的男性来说,存在口腔人乳头瘤病毒(HPV)感染更为普遍,这表明,HPV可通过口-口或口-生殖器传播。 根据麦吉尔大学发表在Cancer Epidemiology, Biomarkers & Prevention(美国癌症研究联盟杂志)上的一项研究表明,对于其女性伴侣存在口腔或生殖器HPV感染的男性来说,口腔人乳头



据研究报道,对于其女性伴侣存在口腔或生殖器HPV感染的男性来说,存在口腔人乳头瘤病毒(HPV)感染更为普遍,这表明,HPV可通过口-口或口-生殖器传播。

根据麦吉尔大学发表在Cancer Epidemiology, Biomarkers & Prevention(美国癌症研究联盟杂志)上的一项研究表明,对于其女性伴侣存在口腔或生殖器HPV感染的男性来说,口腔人乳头瘤病毒(HPV)感染变得更为普遍,这表明,HPV可通过口-口或口-生殖器传播。

麦克吉尔大学的癌症流行病学系教授兼主任Eduardo L. Franco说:“HPV是世界上最常见的性传播疾病,而且是多种癌症的危险因素,包括宫颈癌、阴道癌、口咽(咽喉/扁桃体)癌、肛门癌和阴茎癌”。“了解HPV是如何传播的非常重要,因为它能帮助我们确定谁是HPV易感者以及我们如何帮助他们以及他们的伴侣免于HPV感染,”同时作为医学院肿瘤科主任的Franco补充道,“我们的研究工作更加证明了HPV可在性生活中通过口-口和口-生殖器接触传播”。

男性吸烟者HPV感染率更高

Franco领导的研究小组调查了222名男性以及他们的女性伴侣,发现男性调查者口腔HPV感染的发病率为7.2%。下面几种情况下男性患病率较高,男性吸烟者(12.2%)、非一个固定伴侣者(17.9%)、以及其女性伴侣为口腔HPV感染者(28.6%)和/或生殖器HPV感染者(11.5%)。在这222名调查者中,130名调查者的伴侣为HPV感染者。

HPV16是最常见致癌HPV亚型,在本研究的男性中感染率为2.3%,对于33名伴侣为生殖器HPV16感染的男性中,其发病率为6.1%。

随着口交频率(从不/很少/较多/总是)增加,女性发病率相应增加,而对于女性伴侣为某种特定HPV亚型感染的男性来说,其发病率则增加了两倍。

Franco在麦吉尔进行了情侣通过异性性行为感染或传播了HPV的研究。参与者中,年轻女同学年龄在18-24岁,她们的男性伴侣参与了2005-2011的研究。被调查者完成关于他们性经历的问卷并提供口腔和阴道或阴茎/阴囊样本。研究人员分析了36例粘膜型HPV样本。
有一个固定女性伴侣的52名非吸烟者男性检测出HPV感染,其伴侣没有口腔或生殖器HPV感染。

原始出处:


Dahlstrom KR1, Burchell AN2, Ramanakumar AV1, Rodrigues A1, Tellier PP3, Hanley J4, Coutlée F5, Franco EL6.Sexual transmission of oral human papillomavirus infection among men.Cancer Epidemiol Biomarkers Prev. 2014 Dec;23(12):2959-64. doi: 10.1158/1055-9965.EPI-14-0386. Epub 2014 Nov 12.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=125429, encodeId=6b30125429a2, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 14:38:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917123, encodeId=5e78191e12333, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Apr 26 22:10:00 CST 2015, time=2015-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906632, encodeId=b37e1906632eb, content=<a href='/topic/show?id=879e690e29a' target=_blank style='color:#2F92EE;'>#生殖器#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69072, encryptionId=879e690e29a, topicName=生殖器)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, createdName=chendoc242, createdTime=Sat Jan 02 01:10:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370818, encodeId=83c213e08185f, content=<a href='/topic/show?id=9c39864991e' target=_blank style='color:#2F92EE;'>#致癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86499, encryptionId=9c39864991e, topicName=致癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Sat Jan 31 06:10:00 CST 2015, time=2015-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14840, encodeId=149c14840d6, content=都是HPV, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Thu Jan 29 20:55:00 CST 2015, time=2015-01-29, status=1, ipAttribution=)]
    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

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  2. [GetPortalCommentsPageByObjectIdResponse(id=125429, encodeId=6b30125429a2, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 14:38:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917123, encodeId=5e78191e12333, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Apr 26 22:10:00 CST 2015, time=2015-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906632, encodeId=b37e1906632eb, content=<a href='/topic/show?id=879e690e29a' target=_blank style='color:#2F92EE;'>#生殖器#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69072, encryptionId=879e690e29a, topicName=生殖器)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, createdName=chendoc242, createdTime=Sat Jan 02 01:10:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370818, encodeId=83c213e08185f, content=<a href='/topic/show?id=9c39864991e' target=_blank style='color:#2F92EE;'>#致癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86499, encryptionId=9c39864991e, topicName=致癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Sat Jan 31 06:10:00 CST 2015, time=2015-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14840, encodeId=149c14840d6, content=都是HPV, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Thu Jan 29 20:55:00 CST 2015, time=2015-01-29, status=1, ipAttribution=)]
    2015-04-26 sunylz
  3. [GetPortalCommentsPageByObjectIdResponse(id=125429, encodeId=6b30125429a2, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 14:38:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917123, encodeId=5e78191e12333, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Apr 26 22:10:00 CST 2015, time=2015-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906632, encodeId=b37e1906632eb, content=<a href='/topic/show?id=879e690e29a' target=_blank style='color:#2F92EE;'>#生殖器#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69072, encryptionId=879e690e29a, topicName=生殖器)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, createdName=chendoc242, createdTime=Sat Jan 02 01:10:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370818, encodeId=83c213e08185f, content=<a href='/topic/show?id=9c39864991e' target=_blank style='color:#2F92EE;'>#致癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86499, encryptionId=9c39864991e, topicName=致癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Sat Jan 31 06:10:00 CST 2015, time=2015-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14840, encodeId=149c14840d6, content=都是HPV, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Thu Jan 29 20:55:00 CST 2015, time=2015-01-29, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=125429, encodeId=6b30125429a2, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 14:38:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917123, encodeId=5e78191e12333, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Apr 26 22:10:00 CST 2015, time=2015-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906632, encodeId=b37e1906632eb, content=<a href='/topic/show?id=879e690e29a' target=_blank style='color:#2F92EE;'>#生殖器#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69072, encryptionId=879e690e29a, topicName=生殖器)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, createdName=chendoc242, createdTime=Sat Jan 02 01:10:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370818, encodeId=83c213e08185f, content=<a href='/topic/show?id=9c39864991e' target=_blank style='color:#2F92EE;'>#致癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86499, encryptionId=9c39864991e, topicName=致癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Sat Jan 31 06:10:00 CST 2015, time=2015-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14840, encodeId=149c14840d6, content=都是HPV, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Thu Jan 29 20:55:00 CST 2015, time=2015-01-29, status=1, ipAttribution=)]
    2015-01-31 jambiya
  5. [GetPortalCommentsPageByObjectIdResponse(id=125429, encodeId=6b30125429a2, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 14:38:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917123, encodeId=5e78191e12333, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Apr 26 22:10:00 CST 2015, time=2015-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906632, encodeId=b37e1906632eb, content=<a href='/topic/show?id=879e690e29a' target=_blank style='color:#2F92EE;'>#生殖器#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69072, encryptionId=879e690e29a, topicName=生殖器)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, createdName=chendoc242, createdTime=Sat Jan 02 01:10:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370818, encodeId=83c213e08185f, content=<a href='/topic/show?id=9c39864991e' target=_blank style='color:#2F92EE;'>#致癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86499, encryptionId=9c39864991e, topicName=致癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Sat Jan 31 06:10:00 CST 2015, time=2015-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14840, encodeId=149c14840d6, content=都是HPV, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Thu Jan 29 20:55:00 CST 2015, time=2015-01-29, status=1, ipAttribution=)]
    2015-01-29 223.104.5.**

    都是HPV

    0

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认真刷牙可以保护口腔健康,而且医学界研究发现,刷牙刷得好,对心脏健康也有关联益处。最近美国的一项研究又发现,认真刷牙可以帮助对抗关节炎。 美国路易斯维尔大学的研究人员在新一期在线期刊《科学公共图书馆—病原体》上介绍说,诱发牙周疾病的一种主要细菌“牙龈卟啉单胞菌”,会产生一种特定的酶。在这种酶的催化下,某些特定蛋白质的“残基”(蛋白质上的特定单元)会转变为瓜氨酸。这时机体就会把这样的蛋白质误认作“入

Guardian:口腔性行为与喉癌有关?

Michael Douglas: "because, without wanting to get too specific, this particular cancer is caused by HPV, which actually comes about from cunnilingus." 多年来,人们认为吸烟和饮酒是导致喉癌的主要危险因素。但是,周一,英国报纸《卫报》(Th