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CLIN CANCER RES：肺大细胞神经内分泌癌分子亚型可预测化疗反应

2018-01-08 MedSci MedSci原创

大细胞神经内分泌癌分子亚型化疗反应
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大细胞神经内分泌癌是肺癌中一种罕见的亚型，其合理的治疗方案尚存在争议。之前的遗传学研究发现了两类不同的大细胞神经内分泌癌（LCNEC）分子亚型：RB1突变型（通常存在TP53共突变）和RB1野生型。CLIN CANCER RES近期发表了一篇文章，研究这类分子亚型是否对化疗结果由预测价值。

大细胞神经内分泌癌是肺癌中一种罕见的亚型，其合理的治疗方案尚存在争议。之前的遗传学研究发现了两类不同的大细胞神经内分泌癌（LCNEC）分子亚型：RB1突变型（通常存在TP53共突变）和RB1野生型。CLIN CANCER RES近期发表了一篇文章，研究这类分子亚型是否对化疗结果由预测价值。

作者回顾性收集了临床数据和肿瘤标本。通过病理在232例患者中确诊了148例LCNEC患者。在79例患者中进行了TP53，RB1，STK11，KEAP1基因的二代基因测序，在109例患者中使用免疫组化检测了RB1和P16，并将结果与总生存和无进展生存相联系，并根据不同治疗策略进行分层。治疗策略有铂类+吉西他滨或紫杉烷（NSCLC-GEM/TAX）和铂类-依托泊苷（SCLC-PE）两种。研究结果发现，在47%的患者中发现RB1突变，在72%的患者中发现RB1蛋白缺失。对RB1野生型LCNEC患者，接受NSCLC-GEM/TAX化疗的总生存显着优于接受SCLC-PE化疗的患者。在表达RB1蛋白的患者中观察到了相似的结果。RB1染色或P16缺失也有相似结果。在RB1突变或缺失RB1蛋白的LCNEC患者中化疗结果相同。

文章最后认为，携带野生型RB1基因或表达RB1蛋白的LCNEC肿瘤患者进行NSCLC-GEM/TAX治疗效果优于SCLC-PE化疗。但是RB1突变或蛋白表达缺失的患者中两种方案并无区别。

原始出处：
Jules L.Derks,Noemie Leblay,et al.Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome.CLIN CANCER RES.January 2018 doi:10.1158/1078-0432.CCR-17-1921

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    2018-04-29 feifers

    #大细胞神经内分泌癌#

    0

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    2018-02-24 gwc392

    #分泌#

    0

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    2018-06-27 lfcmxl

    #神经内分泌癌#

    0

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    2018-05-13 lily1616

    #神经内分泌#

    0

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    2018-01-16 zjshifan_98647306

    #化疗反应#

    0

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    2018-01-14 jyzxjiangqin

    肺大细胞神经内分泌.

    0

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    2018-01-10 HinsMax

    #分子亚型#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2060950, encodeId=02bf20609500c, content=<a href='/topic/show?id=bbce43822dd' target=_blank style='color:#2F92EE;'>#大细胞神经内分泌癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43822, encryptionId=bbce43822dd, topicName=大细胞神经内分泌癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1f1d390, createdName=feifers, createdTime=Sun Apr 29 12:01:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682400, encodeId=3c1f1682400a6, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Sat Feb 24 21:01:00 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701100, encodeId=76db1e01100eb, content=<a href='/topic/show?id=275ae4200bf' target=_blank style='color:#2F92EE;'>#神经内分泌癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74200, encryptionId=275ae4200bf, topicName=神经内分泌癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8efd30335749, createdName=lfcmxl, createdTime=Wed Jun 27 12:01:00 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953722, encodeId=519d1953e2297, content=<a href='/topic/show?id=9bdbe41946e' target=_blank style='color:#2F92EE;'>#神经内分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74194, encryptionId=9bdbe41946e, topicName=神经内分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Sun May 13 16:01:00 CST 2018, time=2018-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973574, encodeId=2c6019e357443, content=<a href='/topic/show?id=41b03354870' target=_blank style='color:#2F92EE;'>#化疗反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33548, encryptionId=41b03354870, topicName=化疗反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99cf2500102, createdName=zjshifan_98647306, createdTime=Tue Jan 16 09:01:00 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278315, encodeId=650d2e831530, content=肺大细胞神经内分泌., beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Jan 14 07:44:42 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339933, encodeId=c74d133993374, content=<a href='/topic/show?id=0ec031565c3' target=_blank style='color:#2F92EE;'>#分子亚型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31565, encryptionId=0ec031565c3, topicName=分子亚型)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Wed Jan 10 07:01:00 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276687, encodeId=19192e6687e1, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Mon Jan 08 19:31:00 CST 2018, time=2018-01-08, status=1, ipAttribution=)]
    2018-01-08 131****1460

    学习了受益匪浅

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