Neurology:多发脑梗死和ICAS对轻微脑卒中或TIA患者有何影响?

2017-02-16 xing.T MedSci原创

由此可见,多发脑梗死和ICAS的存在都与轻微脑卒中或TIA患者90天缺血性卒中发生风险增加有关。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在评估不同类型的梗死和颅内动脉狭窄(ICAS)与急性缺血性小卒中和TIA预后之间的相关性。

研究人员从急性非致残性脑血管事件高危患者氯吡格雷(CHANCE研究)试验中获得分析数据。该研究共有1089例患者,来自于114个参与研究地区中的45个地区,在研究之初接受MRI/血管造影的患者被纳入进行亚组分析。研究人员记录了每一个参与者的脑梗死与ICAS的类型。该研究的主要疗效结局指标为90天随访期间发生的缺血性卒中。研究人员采用多变量Cox回归模型评估了成像类型与患者预后之间的关系。

在被纳入亚组分析的1089例患者中,93例(8.5%)患者在90天内出现复发性缺血性卒中。与那些没有梗死或ICAS的患者相比,单一脑梗死伴有ICAS的患者(11.9% vs. 1.3%,风险比[HR]为6.25,95%可信区间[CI]为1.40-27.86,P=0.02)和单一脑梗死不伴有ICAS的患者(6.8% vs. 1.3%,HR为4.65,95%CI为1.05-20.64,P=0.04)在90天与缺血性卒中的风险增加相关。多发脑梗死和ICAS的患者在90天发生缺血性卒中的风险增加约13倍(18% vs. 1.3%,HR为13.14,95%CI为2.96–58.36,P<0.001)。

由此可见,多发脑梗死和ICAS的存在都与轻微脑卒中或TIA患者90天缺血性卒中发生风险增加有关。

原始出处:

Yuesong Pan,et al. Association of multiple infarctions and ICAS with outcomes of minor stroke and TIA. Neurology.    http://dx.doi.org/10.1212/WNL.0000000000003719

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    2017-12-17 yinhl1978
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    2017-08-26 马龙
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    2017-02-18 karmond
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    2017-02-18 手留余香
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    2017-02-18 yaanren