Nat Genet.:科学家研发食道癌早期检测新方法

2014-07-10 佚名 生物360

在线发表于《自然-遗传学》上的一项报告介绍了一种用于食道癌早期检测的新方法的研发。该检测方法是在以有关食道癌中最早发生突变的基因的一些发现为基础开发的。 食道癌是世界最常见癌症之一,其致病因素很多,包括胃酸倒流和吸烟等。目前用于检测食道癌的方法是内镜检测,但是效果并不好。 Rebecca Fitzgerald等人研究了食道癌临床样本中的基因突变,并将其与食道癌早期阶段样本中的突变进行了比较。他们发

在线发表于《自然-遗传学》上的一项报告介绍了一种用于食道癌早期检测的新方法的研发。该检测方法是在以有关食道癌中最早发生突变的基因的一些发现为基础开发的。

食道癌是世界最常见癌症之一,其致病因素很多,包括胃酸倒流和吸烟等。目前用于检测食道癌的方法是内镜检测,但是效果并不好。

Rebecca Fitzgerald等人研究了食道癌临床样本中的基因突变,并将其与食道癌早期阶段样本中的突变进行了比较。他们发现有两种基因可用于区分食道癌前期阶段和末期阶段:TP53基因存在于具有癌症早期信号的病患中,但没有出现在具有食道癌良性前兆即巴瑞特氏食道症的患者体内;另一种基因是SMAD4,其只在癌症被确认的样本中发生突变。研究人员利用这项发现开发出一种用于食道癌早期检测的新方法。

原始出处:

Jamie M J Weaver, Caryn S Ross-Innes, Nicholas Shannon, Andy G Lynch, Tim Forshew, Mariagnese Barbera, Muhammed Murtaza, Chin-Ann J Ong, Pierre Lao-Sirieix, Mark J Dunning, Laura Smith, Mike L Smith, Charlotte L Anderson, Benilton Carvalho, Maria O'Donovan, Timothy J Underwood, Andrew P May, Nicola Grehan, Richard Hardwick, Jim Davies, Arusha Oloumi, Sam Aparicio, Carlos Caldas, Matthew D Eldridge, Paul A W Edwards, Nitzan Rosenfeld, Simon Tavaré & Rebecca C Fitzgerald. Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis. Nature Genetics, 22 June 2014;

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    2015-04-08 liye789132251
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    2014-12-13 canlab
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    2015-05-29 cy0324
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    2014-07-14 Anneanne

    太好了!正在找思路呢!真是明灯啊

    0

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    2014-07-12 lqvr

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