Int Immunopharmacol:黄芩新素能够减轻卵清蛋白诱导的过敏性鼻炎症状

2017-09-19 AlexYang MedSci原创

过敏性鼻炎是一种常见的多样化的慢性上呼吸道障碍疾病,并且是一种lgE调控的炎症,可以通过一种或者多种鼻部症状,如打喷嚏、鼻痒、流鼻涕、鼻液溢、后鼻排水和鼻塞来进行鉴定。最近,有研究人员调查了黄芩新素 II (SCF II )对上呼吸道炎症、Th2细胞激素和在卵清蛋白(OVA)诱导的过敏性鼻炎(AR)小鼠模型体内NF-κB 信号的影响。研究发现,OVA诱导的AR小鼠鼻部症状、嗜酸细胞和肥大细胞渗透到

过敏性鼻炎是一种常见的多样化的慢性上呼吸道障碍疾病,并且是一种lgE调控的炎症,可以通过一种或者多种鼻部症状,如打喷嚏、鼻痒、流鼻涕、鼻液溢、后鼻排水和鼻塞来进行鉴定。最近,有研究人员调查了黄芩新素 II (SCF II )对上呼吸道炎症、Th2细胞激素和在卵清蛋白(OVA)诱导的过敏性鼻炎(AR)小鼠模型体内NF-κB 信号的影响。研究发现,OVA诱导的AR小鼠鼻部症状、嗜酸细胞和肥大细胞渗透到了鼻腔、OVA特异性lgE/lgG1和血清中的组织胺、Th2细胞激素包括IL-13和GATA3、在NALF和肺实质中的NF-κB信号均增加。有趣的是,SCF II 的治疗减少了OVA特异性的lgE/lgG1和血清组织胺水平,并且减少了Th2细胞激素水平和在NALF和肺实质中的NF-κB信号,还减少了鼻组织和肺中组织病理学的变化。同样,地塞米松也可抑制此类病理性状的增加。最后,研究人员指出,该研究的结果表明了SCF II 也许可通过阻塞Th2细胞激素产生、NF-κB信号通路和肥大细胞释放来改善AR小鼠模型中上的呼吸道过敏炎症。总之,研究人员表明了SCF II 也许可以作为Th2调控的或者肥大细胞

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    2018-06-13 jj000001
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    2018-05-14 yb6560
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1650264, encodeId=f2c4165026486, content=<a href='/topic/show?id=b5de3690069' target=_blank style='color:#2F92EE;'>#卵清蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36900, encryptionId=b5de3690069, topicName=卵清蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=430623995054, createdName=gostraight, createdTime=Mon Jul 09 10:10:00 CST 2018, time=2018-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787323, encodeId=99ff1e8732327, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Wed Jun 13 00:10:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1996048, encodeId=ac161996048f5, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Mon May 14 19:10:00 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046882, encodeId=3fee2046882b1, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Mon May 07 05:10:00 CST 2018, time=2018-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908315, encodeId=a982190831520, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sun Jul 29 15:10:00 CST 2018, time=2018-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788247, encodeId=32991e8824778, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Tue Sep 04 09:10:00 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245776, encodeId=8cda245e7618, content=套路....都不想吐槽了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e502075746, createdName=营养医师, createdTime=Tue Sep 19 21:28:21 CST 2017, time=2017-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245768, encodeId=b5a8245e68a1, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Sep 19 20:58:16 CST 2017, time=2017-09-19, status=1, ipAttribution=)]
    2017-09-19 营养医师

    套路....都不想吐槽了

    0

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    2017-09-19 惠映实验室

    学习了.谢谢.

    0