Ophthalmology:眼角膜移植效果或与捐赠者年龄关系不大

2013-12-05 林小春 新华网

如果你需要眼角膜移植来改善视力,也许不用太过担心捐赠者的年龄。美国《眼科学》杂志15日发表的一项新研究表明,来自71岁捐赠者的角膜在移植10年后,其健康程度与来自35岁捐赠者的角膜大体相似。 美国国家眼科研究所资助发起的这项研究共分析了663名接受角膜移植手术的患者,结果发现,移植的角膜来自12岁至65岁和66岁至75岁两个年龄段捐赠者的患者,手术后10年的移植成功率类似,分别为77%与71%。

如果你需要眼角膜移植来改善视力,也许不用太过担心捐赠者的年龄。美国《眼科学》杂志15日发表的一项新研究表明,来自71岁捐赠者的角膜在移植10年后,其健康程度与来自35岁捐赠者的角膜大体相似。

美国国家眼科研究所资助发起的这项研究共分析了663名接受角膜移植手术的患者,结果发现,移植的角膜来自12岁至65岁和66岁至75岁两个年龄段捐赠者的患者,手术后10年的移植成功率类似,分别为77%与71%。【原文下载

目前,绝大部分角膜捐赠者的年龄介于34岁至71岁之间。新研究表明,来自这一年龄段捐赠者的角膜移植手术10年后的成功率为75%。

不过当把研究的人群按年龄进一步细分时,研究人员确实发现了些许差别:移植的角膜来自12岁至33岁捐赠者的患者,手术后10年的移植成功率升至96%;来自72岁至75岁捐献者的患者,手术后10年的移植成功率降至62%。

但研究负责人之一、辛辛那提大学爱德华·霍华德教授依然认为,总体而言,年老的和年轻的角膜组织在移植效果上大体相似,“我们的研究支持将角膜捐赠的年龄扩展至65岁以上”。

美国国家眼科研究所表示,医生们做角膜移植手术通常选择来自年轻捐赠者的角膜,有些医生甚至设置了严格的捐赠年龄上限,50岁以上的就拒绝使用。这项研究于2000年启动,那时多数医生不愿意接受来自65岁以上捐赠者的角膜。 

原文出处

Writing Committee for the Cornea Donor Study Research Group, Mannis MJ, Holland EJ, Gal RL, Dontchev M, Kollman C, Raghinaru D, Dunn SP, Schultze RL, Verdier DD, Lass JH, Raber IM, Sugar J, Gorovoy MS, Sugar A, Stulting RD, Montoya MM, Penta JG, Benetz BA, Beck RW.The effect of donor age on penetrating keratoplasty for endothelial disease: graft survival after 10 years in the cornea donor study.Ophthalmology. 2013 Dec;【原文下载

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    2013-12-07 snowpeakxu
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