Circ-Heart Fail:急性失代偿性射血分数正常心衰患者风险预测!

2017-12-23 xing.T MedSci原创

由此可见,射血分数正常的心力衰竭患者急性失代偿期死亡率较高,三分之一的患者在一年内死亡。这个预测工具可能允许对高危患者进行更好的区分。

专门用于住院治疗的射血分数降低正常的心力衰竭患者风险预测模型的研究仍是缺乏的。近日,心血管领域权威杂志Circ-Heart Fail上发表了一篇研究文章,研究人员分析的数据来自ARIC(社区动脉粥样硬化风险)研究心衰社区监视系统,旨在创建和验证风险评分来预测入院时为急性失代偿性心衰但射血分数正常(射血分数≥50%)的≥55岁患者死亡率。

改良版本的急性心力衰竭风险预测模型来自于EFFECT(有效心脏治疗的增强反馈)研究,作为28天和1年死亡率的复合预测指标并且在逐步Logistic回归中与其他潜在的预测因素一起评价。

衍生样本包含了1852例从2005年到2011年期间的住院治疗患者(平均年龄为77岁,65%为妇女;74%为白人)。风险评分由确定的预测因子组建,并在住院治疗中进行验证,从2012年到2013年(n=821)。衍生样本和验证样本中28天死亡率分别为11%和8%;1年死亡率分别为34%和31%。改良版的疗效评分,包括年龄、收缩压、血尿素氮、钠、脑血管病、慢性阻塞性肺疾病和血红蛋白,是死亡率的有力预测因素。另一个重要的预测因素为28天和1年死亡率是缺氧。在推导样本(28天和1年死亡率的曲线下面积分别为0.76和0.72)和验证样本(曲线下面积分别为0.73和0.71)中,风险评分得到了较好地校准,具有较好的区分能力。

由此可见,射血分数正常的心力衰竭患者急性失代偿期死亡率较高,三分之一的患者在一年内死亡。这个预测工具可能允许对高危患者进行更好的区分。

原始出处:

Tonje Thorvaldsen,et al. Predicting Risk in Patients Hospitalized for Acute Decompensated Heart Failure and Preserved Ejection Fraction The Atherosclerosis Risk in Communities Study Heart Failure Community Surveillance. Circulation:heart failure. 2017. https://doi.org/10.1161/CIRCHEARTFAILURE.117.003992

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    2017-12-24 zhaojie88
  5. 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  8. 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    2017-12-23 hhh678

    henhao

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Dec 23 08:50:05 CST 2017, time=2017-12-23, status=1, ipAttribution=)]
    2017-12-23 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

  10. 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objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Dec 23 08:50:05 CST 2017, time=2017-12-23, status=1, ipAttribution=)]
    2017-12-23 龙胆草

    学习谢谢分享

    0