Breast Cancer Res:辟谣!大型前瞻性研究发现女性心理压力并不会增加乳腺癌的发病风险

2016-07-24 sunshine 译 MedSci原创

女性诊断为乳腺癌后通常将其病因归咎于心理压力,但是支持此看法的研究甚少。本研究旨在探究常有心理压力及不良生活事件是否会影响日后乳腺癌的发生风险。采用前瞻性研究共纳入了英国10.6万名女性,均匀随访6.1年,其间1783名女性发生乳腺癌。使用Cox比例风险模型评估相对风险来作为风险比。结果并未发现乳腺癌发病风险与心理压力的频率相关。随访前5年期间,近亲死亡的乳腺癌危险降低13%(RR:0.87,95

女性诊断为乳腺癌后通常将其病因归咎于心理压力,但是支持此看法的研究甚少。本研究旨在探究常有心理压力及不良生活事件是否会影响日后乳腺癌的发生风险。

采用前瞻性研究共纳入了英国10.6万名女性,均匀随访6.1年,其间1783名女性发生乳腺癌。使用Cox比例风险模型评估相对风险来作为风险比。

结果并未发现乳腺癌发病风险与心理压力的频率相关。随访前5年期间,近亲死亡的乳腺癌危险降低13%(RR:0.87,95% CI:0.78~0.97),但与配偶/伴侣或密友死亡、个人疾病/外伤、或离异/分离无关。离异与雌激素受体阴性呈正相关(RR:1.54,95% CI:1.01~2.34),但与雌激素受体阳性乳腺癌无关。研究对象20岁前其母亲去世者的乳腺癌发生危险增加31%(RR:1.31,95% CI:1.02~1.67),但与爸爸去世时间无关,排除其母亲为乳腺癌或卵巢癌患者后危险增加17%(RR:1.17,95% CI:0.85~1.61)。

总而言之,该大样本前瞻性研究并未发现乳腺癌危险与过去5年女性的心理压力水平、不良生活事件、孩童或青少年时期父母逝世相关。

原始出处:

Schoemaker MJ, Jones ME, Wright LB, et al. Psychological stress, adverse life events and breast cancer incidence: a cohort investigation in 106 000 women in the United Kingdom. Breast Cancer Res2016; doi:10.1186/s13058-016-0733-1.


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  5. 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    2016-09-04 feather87
  6. 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    2016-09-10 1e10c84am36(暂无匿称)

    好文章,百姓也能从中学到好多医学知识

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=1630810, encodeId=578c1630810f7, content=<a href='/topic/show?id=96875113eb4' target=_blank style='color:#2F92EE;'>#心理压力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51137, encryptionId=96875113eb4, topicName=心理压力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3e721584542, createdName=yuanming14, createdTime=Tue Jul 26 01:59:00 CST 2016, time=2016-07-26, status=1, ipAttribution=)]
    2016-09-06 李东泽

    很好,不错,以后会多学习

    0

  8. 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GetPortalCommentsPageByObjectIdResponse(id=1630810, encodeId=578c1630810f7, content=<a href='/topic/show?id=96875113eb4' target=_blank style='color:#2F92EE;'>#心理压力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51137, encryptionId=96875113eb4, topicName=心理压力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3e721584542, createdName=yuanming14, createdTime=Tue Jul 26 01:59:00 CST 2016, time=2016-07-26, status=1, ipAttribution=)]
    2016-08-03 oo902

    什么样的结果都有

    0

  9. 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GetPortalCommentsPageByObjectIdResponse(id=1630810, encodeId=578c1630810f7, content=<a href='/topic/show?id=96875113eb4' target=_blank style='color:#2F92EE;'>#心理压力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51137, encryptionId=96875113eb4, topicName=心理压力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3e721584542, createdName=yuanming14, createdTime=Tue Jul 26 01:59:00 CST 2016, time=2016-07-26, status=1, ipAttribution=)]
    2016-07-26 zhaojie88
  10. 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