J Med Case Reports:甲状腺全切术后的Graves病

2016-05-25 MedSci MedSci原创

甲状腺切除术后的甲状腺毒症主要是医源性的。较少见的是高功能甲状腺组织的残留或者异位甲状腺组织所致。研究人员报道的这一病例是非毒性甲状腺肿行甲状腺全切后出现持续7年的纵膈甲状腺导致的Graves病。一位67岁的白人妇女出现心悸,乏力,体重下降。她在60岁时因非毒性结节性甲状腺肿行甲状腺全切术,当时无恶变倾向。术后服用左旋甲状腺素100μg/天。她出现心动过速,无颈部肿块和眼部损害,促甲状腺素水平被抑

甲状腺切除术后的甲状腺毒症主要是医源性的。较少见的是高功能甲状腺组织的残留或者异位甲状腺组织所致。研究人员报道的这一病例是非毒性甲状腺肿行甲状腺全切后出现持续7年的纵膈甲状腺导致的Graves病。

一位67岁的白人妇女出现心悸,乏力,体重下降。她在60岁时因非毒性结节性甲状腺肿行甲状腺全切术,当时无恶变倾向。术后服用左旋甲状腺素100μg/天。她出现心动过速,无颈部肿块和眼部损害,促甲状腺素水平被抑制(0.000μU/ml),游离甲状腺素(3.22ng/dl)和游离三碘甲状腺原氨酸(8.46pg/ml)升高。胸片未发现纵膈增大和气管偏移。患者停用左旋甲状腺素10天后,甲状腺素水平和三碘甲状腺原氨酸水平并无改善。甲状腺球蛋白升至294mg/ml。颈部超声提示无甲状腺残留。抗甲状腺素受体升高至19.7U/l。人体显像提示胸腔内放射性碘摄取增加,CT证实纵膈内有一大小60*40mm肿块。于是开始服用他巴唑10mg/d治疗,3月后甲状腺功能正常,然后行手术切除。病检提示无恶变。

虽然甲状腺全切术后的甲状腺毒症常常是由于补充了过多的甲状腺素,但是甲状腺功能亢进却是很少见的,因此我们应该注意。

原始出处:

Cunha FM,Rodrigues E,Oliveira J,Saavedra A,Vinhas LS,Carvalho D.Graves' Disease in a Mediastinal Mass Presenting After Total Thyroidectomy for Nontoxic Multinodular Goiter.J Med Case Reports. 2016;10(70)

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1782638, encodeId=b2461e8263865, content=<a href='/topic/show?id=cff1413333' target=_blank style='color:#2F92EE;'>#case report#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4133, encryptionId=cff1413333, topicName=case report)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Oct 31 22:16:00 CST 2016, time=2016-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039589, encodeId=33402039589bf, content=<a href='/topic/show?id=7ae88244a6' target=_blank style='color:#2F92EE;'>#Graves#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8244, encryptionId=7ae88244a6, topicName=Graves)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Wed Jun 08 20:16:00 CST 2016, time=2016-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027921, encodeId=7221202e9211e, content=<a href='/topic/show?id=7c9a41324e' target=_blank style='color:#2F92EE;'>#case#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4132, encryptionId=7c9a41324e, topicName=case)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62a7397, createdName=charl1234567, createdTime=Wed Nov 23 23:16:00 CST 2016, time=2016-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88147, encodeId=45fc8814e3b, content=好文章,得多学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53751677671, createdName=沉心多思, createdTime=Thu Jun 02 02:40:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464158, encodeId=0f0814641588d, content=<a href='/topic/show?id=9a0982481a' target=_blank style='color:#2F92EE;'>#Graves病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8248, encryptionId=9a0982481a, topicName=Graves病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25146601811, createdName=aliceclz, createdTime=Fri May 27 08:16:00 CST 2016, time=2016-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606926, encodeId=f075160692691, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri May 27 08:16:00 CST 2016, time=2016-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624778, encodeId=be4c1624e7862, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Fri May 27 08:16:00 CST 2016, time=2016-05-27, status=1, ipAttribution=)]
    2016-06-08 xinmeili
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    2016-11-23 charl1234567
  4. [GetPortalCommentsPageByObjectIdResponse(id=1782638, encodeId=b2461e8263865, content=<a href='/topic/show?id=cff1413333' target=_blank style='color:#2F92EE;'>#case report#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4133, encryptionId=cff1413333, topicName=case report)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Oct 31 22:16:00 CST 2016, time=2016-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039589, encodeId=33402039589bf, content=<a href='/topic/show?id=7ae88244a6' target=_blank style='color:#2F92EE;'>#Graves#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8244, encryptionId=7ae88244a6, topicName=Graves)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Wed Jun 08 20:16:00 CST 2016, time=2016-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027921, encodeId=7221202e9211e, content=<a href='/topic/show?id=7c9a41324e' target=_blank style='color:#2F92EE;'>#case#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4132, encryptionId=7c9a41324e, topicName=case)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62a7397, createdName=charl1234567, createdTime=Wed Nov 23 23:16:00 CST 2016, time=2016-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88147, encodeId=45fc8814e3b, content=好文章,得多学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53751677671, createdName=沉心多思, createdTime=Thu Jun 02 02:40:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464158, encodeId=0f0814641588d, content=<a href='/topic/show?id=9a0982481a' target=_blank style='color:#2F92EE;'>#Graves病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8248, encryptionId=9a0982481a, topicName=Graves病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25146601811, createdName=aliceclz, createdTime=Fri May 27 08:16:00 CST 2016, time=2016-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606926, encodeId=f075160692691, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri May 27 08:16:00 CST 2016, time=2016-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624778, encodeId=be4c1624e7862, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Fri May 27 08:16:00 CST 2016, time=2016-05-27, status=1, ipAttribution=)]
    2016-06-02 沉心多思

    好文章,得多学习了!

    0

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    2016-05-27 yaanren

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