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Diabetes Care：短期强化胰岛素治疗可降低2型糖尿病患者血糖变异性

2014-03-05 高晓方 译 医学论坛网

胰岛素2型糖尿病血糖变异性
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加拿大一项研究表明，在早期2型糖尿病患者中，通过短期强化胰岛素治疗(IIT)改善β细胞功能，可降低血糖变异性。论文2月18日在线发表于《糖尿病护理》(Diabetes Care)。此项研究共纳入61例平均病程为3.0年的2型糖尿病患者。受试者均接受为期4周的IIT;IIT由基础地特胰岛素和餐前门冬胰岛素组成。通过每日6次的自测血糖变异系数评估第一和第四周的血糖变异性。利用胰岛素分泌敏感指数-2(I

加拿大一项研究表明，在早期2型糖尿病患者中，通过短期强化胰岛素治疗(IIT)改善β细胞功能，可降低血糖变异性。论文2月18日在线发表于《糖尿病护理》(Diabetes Care)。【原文下载】

此项研究共纳入61例平均病程为3.0年的2型糖尿病患者。受试者均接受为期4周的IIT;IIT由基础地特胰岛素和餐前门冬胰岛素组成。通过每日6次的自测血糖变异系数评估第一和第四周的血糖变异性。利用胰岛素分泌敏感指数-2(ISSI-2)评估IIT前后β细胞功能。



结果显示，在IIT第1周和最后1周之间，55.7%的患者出现血糖变异性降低。血糖变异性变化与β细胞功能变化呈负相关性(P=0.008)。多元线性回归分析显示，ISSI-2变化百分比是唯一与血糖波动变化独立相关的因素。此外，与ISSI-2几乎无变化者相比，ISSI-2 升高≥25%的患者出现血糖波动降低(P=0.006)。

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    2015-02-07 智智灵药

    #BET#

    0

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time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=8090, encodeId=9f44809073, content=这个研究需要谨慎对待！血糖变异的发生和影响是一个慢性过程，强化降糖，对短期的血糖变异有效（同样缓慢降糖，同样也能降低血糖变异性），关键是看长期的血糖变异，是否有获益，甚至长期的并发症！, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=小小糖专家, createdTime=Wed Mar 05 11:22:00 CST 2014, time=2014-03-05, status=1, ipAttribution=)]
    2014-06-27 baoya

    #胰岛#

    0

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time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=8090, encodeId=9f44809073, content=这个研究需要谨慎对待！血糖变异的发生和影响是一个慢性过程，强化降糖，对短期的血糖变异有效（同样缓慢降糖，同样也能降低血糖变异性），关键是看长期的血糖变异，是否有获益，甚至长期的并发症！, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=小小糖专家, createdTime=Wed Mar 05 11:22:00 CST 2014, time=2014-03-05, status=1, ipAttribution=)]
    2014-03-21 木头人513

    #Diabetes#

    0

  4. 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createdName=baoya, createdTime=Fri Jun 27 20:40:00 CST 2014, time=2014-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901190, encodeId=26581901190ab, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Fri Mar 21 15:40:00 CST 2014, time=2014-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1967098, encodeId=bb2a196e09848, content=<a href='/topic/show?id=93708982e76' target=_blank style='color:#2F92EE;'>#血糖变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89827, encryptionId=93708982e76, topicName=血糖变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=869698, createdName=ligang4439, createdTime=Sun Nov 09 05:40:00 CST 2014, time=2014-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636828, encodeId=46131636828d1, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Oct 14 18:40:00 CST 2014, time=2014-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342295, encodeId=889c13422950f, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, 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href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514607, encodeId=202b151460e41, content=<a href='/topic/show?id=c8d68389847' target=_blank style='color:#2F92EE;'>#胰岛素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83898, encryptionId=c8d68389847, topicName=胰岛素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e51610667367, createdName=zjshifan_98647309, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=8090, encodeId=9f44809073, content=这个研究需要谨慎对待！血糖变异的发生和影响是一个慢性过程，强化降糖，对短期的血糖变异有效（同样缓慢降糖，同样也能降低血糖变异性），关键是看长期的血糖变异，是否有获益，甚至长期的并发症！, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=小小糖专家, createdTime=Wed Mar 05 11:22:00 CST 2014, time=2014-03-05, status=1, ipAttribution=)]
    2014-11-09 ligang4439

    #血糖变异#

    0

  5. 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href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514607, encodeId=202b151460e41, content=<a href='/topic/show?id=c8d68389847' target=_blank style='color:#2F92EE;'>#胰岛素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83898, encryptionId=c8d68389847, topicName=胰岛素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e51610667367, createdName=zjshifan_98647309, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=8090, encodeId=9f44809073, content=这个研究需要谨慎对待！血糖变异的发生和影响是一个慢性过程，强化降糖，对短期的血糖变异有效（同样缓慢降糖，同样也能降低血糖变异性），关键是看长期的血糖变异，是否有获益，甚至长期的并发症！, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=小小糖专家, createdTime=Wed Mar 05 11:22:00 CST 2014, time=2014-03-05, status=1, ipAttribution=)]
    2014-10-14 ms9608593228839890

    #DIA#

    0

  6. 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encryptionId=93708982e76, topicName=血糖变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=869698, createdName=ligang4439, createdTime=Sun Nov 09 05:40:00 CST 2014, time=2014-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636828, encodeId=46131636828d1, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Oct 14 18:40:00 CST 2014, time=2014-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342295, encodeId=889c13422950f, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383144, encodeId=38e31383144ab, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473770, encodeId=968414e377063, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514607, encodeId=202b151460e41, content=<a href='/topic/show?id=c8d68389847' target=_blank style='color:#2F92EE;'>#胰岛素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83898, encryptionId=c8d68389847, topicName=胰岛素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e51610667367, createdName=zjshifan_98647309, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=8090, encodeId=9f44809073, content=这个研究需要谨慎对待！血糖变异的发生和影响是一个慢性过程，强化降糖，对短期的血糖变异有效（同样缓慢降糖，同样也能降低血糖变异性），关键是看长期的血糖变异，是否有获益，甚至长期的并发症！, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=小小糖专家, createdTime=Wed Mar 05 11:22:00 CST 2014, time=2014-03-05, status=1, ipAttribution=)]
    2014-03-07 12498dabm77暂无昵称

    #变异#

    0

  7. 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encryptionId=93708982e76, topicName=血糖变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=869698, createdName=ligang4439, createdTime=Sun Nov 09 05:40:00 CST 2014, time=2014-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636828, encodeId=46131636828d1, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Oct 14 18:40:00 CST 2014, time=2014-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342295, encodeId=889c13422950f, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, 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href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514607, encodeId=202b151460e41, content=<a href='/topic/show?id=c8d68389847' target=_blank style='color:#2F92EE;'>#胰岛素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83898, encryptionId=c8d68389847, topicName=胰岛素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e51610667367, createdName=zjshifan_98647309, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=8090, encodeId=9f44809073, content=这个研究需要谨慎对待！血糖变异的发生和影响是一个慢性过程，强化降糖，对短期的血糖变异有效（同样缓慢降糖，同样也能降低血糖变异性），关键是看长期的血糖变异，是否有获益，甚至长期的并发症！, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=小小糖专家, createdTime=Wed Mar 05 11:22:00 CST 2014, time=2014-03-05, status=1, ipAttribution=)]
    2014-03-07 aids213

    #2型糖尿病患者#

    0

  8. 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channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383144, encodeId=38e31383144ab, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473770, encodeId=968414e377063, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514607, encodeId=202b151460e41, content=<a href='/topic/show?id=c8d68389847' target=_blank style='color:#2F92EE;'>#胰岛素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83898, encryptionId=c8d68389847, topicName=胰岛素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e51610667367, createdName=zjshifan_98647309, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=8090, encodeId=9f44809073, content=这个研究需要谨慎对待！血糖变异的发生和影响是一个慢性过程，强化降糖，对短期的血糖变异有效（同样缓慢降糖，同样也能降低血糖变异性），关键是看长期的血糖变异，是否有获益，甚至长期的并发症！, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=小小糖专家, createdTime=Wed Mar 05 11:22:00 CST 2014, time=2014-03-05, status=1, ipAttribution=)]
    2014-03-07 xue8604

    #糖尿病患者#

    0

  9. 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channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383144, encodeId=38e31383144ab, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473770, encodeId=968414e377063, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514607, encodeId=202b151460e41, content=<a href='/topic/show?id=c8d68389847' target=_blank style='color:#2F92EE;'>#胰岛素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83898, encryptionId=c8d68389847, topicName=胰岛素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e51610667367, createdName=zjshifan_98647309, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=8090, encodeId=9f44809073, content=这个研究需要谨慎对待！血糖变异的发生和影响是一个慢性过程，强化降糖，对短期的血糖变异有效（同样缓慢降糖，同样也能降低血糖变异性），关键是看长期的血糖变异，是否有获益，甚至长期的并发症！, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=小小糖专家, createdTime=Wed Mar 05 11:22:00 CST 2014, time=2014-03-05, status=1, ipAttribution=)]
    2014-03-07 zjshifan_98647309

    #胰岛素治疗#

    0

  10. 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href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514607, encodeId=202b151460e41, content=<a href='/topic/show?id=c8d68389847' target=_blank style='color:#2F92EE;'>#胰岛素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83898, encryptionId=c8d68389847, topicName=胰岛素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e51610667367, createdName=zjshifan_98647309, createdTime=Fri Mar 07 01:40:00 CST 2014, time=2014-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=8090, encodeId=9f44809073, content=这个研究需要谨慎对待！血糖变异的发生和影响是一个慢性过程，强化降糖，对短期的血糖变异有效（同样缓慢降糖，同样也能降低血糖变异性），关键是看长期的血糖变异，是否有获益，甚至长期的并发症！, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=小小糖专家, createdTime=Wed Mar 05 11:22:00 CST 2014, time=2014-03-05, status=1, ipAttribution=)]
    2014-03-05 小小糖专家

    这个研究需要谨慎对待！血糖变异的发生和影响是一个慢性过程，强化降糖，对短期的血糖变异有效（同样缓慢降糖，同样也能降低血糖变异性），关键是看长期的血糖变异，是否有获益，甚至长期的并发症！

    0

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