Stroke:房颤与脑卒中患者认知功能障碍的关系

2020-04-21 MedSci原创 MedSci原创

在未经调整和调整后的分析中,既往卒中患者AF与CI或痴呆之间的相关性可能是持续存在的正相关性。异质性水平限制了这些结果的确定性。

心房颤动(AF)是最常见的慢性心律不齐。痴呆和认知障碍(CI)是公共卫生的主要负担。由于人口老龄化,这三种疾病的患病率预计会增加。先前的报道将AF与既往无卒中的患者CI和痴呆风险增加联系在一起。有研究已明确卒中会增加痴呆和CI的风险。目前尚不清楚卒中患者的AF是否会进一步增加痴呆或CI的风险。近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在评估AF对卒中患者痴呆或CI风险的影响。

研究人员检索了Pubmed、Scopus和Cochrane中心等数据库,感兴趣的结局包括痴呆、CI以及痴呆或CI的复合终点。研究人员进行了随机效应模型荟萃分析,还进行了Meta回归分析。研究人员使用Egger检验和漏斗图评估了发表偏倚。

该荟萃分析纳入了14项研究,包含14360名患者(1363名AF患者)。在校正比值比的荟萃分析中,AF与CI(比值比为1.60 [95%CI为1.20-1.24])、痴呆症(比值比为3.11 [95%CI为2.05-4.73])以及CI或痴呆的复合终点(比值比为2.26 [95%CI为1.61-3.19])的风险增加相关。痴呆或CI复合终点的异质性中等(校正分析)。CI终点分析的异质性仅在未经调整的分析中显著,而在经过调整的分析中则中等。痴呆症终点的异质性在未经调整的分析中仅为中等,在经过调整的分析中为零。

由此可见,在未经调整和调整后的分析中,既往卒中患者AF与CI或痴呆之间的相关性可能是持续存在的正相关性。异质性水平限制了这些结果的确定性。

原始出处:

Damianos G. Kokkinidis.Association Between Atrial Fibrillation and Cognitive Impairment in Individuals With Prior Stroke A Meta-Analysis and Meta-Regression Analysis.stroke.2020.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.027815

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    2020-04-22 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2020-04-22 心介

    房颤,临床上碰到很多哦

    0

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