J Pediatr:先天性巨细胞病毒感染在种族和民族之间的差异研究

2018-06-01 AlexYang MedSci原创

最近,有研究人员评估了种族和民族对先天性巨细胞病毒感染(cCMV)的流行度和临床表现的影响。研究在2007年到2012年进行,共包括了100332名婴儿,他们来自7个医疗中心,并且在医院时进行了cCMV筛选。研究发现,cCMV在群体中的总流行度为每1000人有4.5人患有(95% CI, 4.1-4.9)。黑人婴儿具有最高水平的cCMV流行度(每1000人有9.5人;95% CI, 8.3-11.

最近,有研究人员评估了种族和民族对先天性巨细胞病毒感染(cCMV)的流行度和临床表现的影响。

研究在2007年到2012年进行,共包括了100332名婴儿,他们来自7个医疗中心,并且在医院时进行了cCMV筛选。研究发现,cCMV在群体中的总流行度为每1000人有4.5人患有(95% CI, 4.1-4.9)。黑人婴儿具有最高水平的cCMV流行度(每1000人有9.5人;95% CI, 8.3-11.0),之后为混血婴儿(每1000人有7.8人;95% CI, 4.7-12.0)。在非西班牙白种人婴儿中观察到了显著更低的流行度(每1000人有3人; 95% CI, 2.4-3.6)以及亚洲婴儿(每1000人有1人,95% CI, 0.3-2.5)。在调整了社会经济状态和孕妇年龄之后,黑人婴儿与非西班牙白人婴儿相比更可能患有cCMV(调整后流行度OR,0.7;95% CI, 0.5-1.0)。然而,在种族/民族群组之间,研究人员在有症状的cCMV(9.6%)和感官听力损失(7.8%)上没有发现显著的差异。

最后,研究人员指出,cCMV在种族和民族之间存在着明显的差异,甚至是调整过社会经济状态和孕妇年龄之后仍旧存在。虽然在感染上有显著差异,但是不同的种族和民族之间在新生儿疾病和听力损失比例上是相似的。

原始出处:

Fowler KB, Ross SA, Shimamura M et al. Racial and Ethnic Differences in the Prevalence of Congenital Cytomegalovirus Infection. J Pediatr. 18 May 2018.

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    2019-02-10 feather89
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    2018-06-03 huirong
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    2018-06-03 wwzzly

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