Hypertension:动态血压再评估可改善慢性肾病患者肾脏危险分层

2015-07-22 小田 译 医学论坛网

在未透析的慢性肾病患者中,动态血压(ABP)可更好地预测患者预后,但ABP的再评估是否能进一步改善预后尚不明确。近期的一项研究回答了上述问题,该研究表明,在未透析的慢性肾病患者中,1年时的ABP再评估可进一步改善肾脏预后;尤其是对那些基线时血压未得到控制的患者应考虑ABP的再评估。相关论文7月6日在线发表于《高血压》(HYPERTENSION)杂志。 该研究入组了182例未透析的慢性肾病高血压连

在未透析的慢性肾病患者中,动态血压(ABP)可更好地预测患者预后,但ABP的再评估是否能进一步改善预后尚不明确。近期的一项研究回答了上述问题,该研究表明,在未透析的慢性肾病患者中,1年时的ABP再评估可进一步改善肾脏预后;尤其是对那些基线时血压未得到控制的患者应考虑ABP的再评估。相关论文7月6日在线发表于《高血压》(HYPERTENSION)杂志。

该研究入组了182例未透析的慢性肾病高血压连续患者,并在12个月接受了2次ABP检测,在基线复合肾脏终点(死亡、长期透析和估算的肾小球滤过率下降≥40%)风险评估后1年进行第2次ABP检测,后者结果纳入危险分层加强评估中。将两次ABP检测的白天和夜间收缩压结果差异加入包含基线ABP水平的生存模型中。计算净重新分类改善情况。

结果显示,受试者年龄为65.6±13.4岁,有糖尿病和既往心血管事件病史的比例分别都为36%,估算的肾小球滤过率为42.2±19.6 mL/min • 1.73 m2,诊室血压为145±18/80±11 mm Hg。

在12个月时,基线ABP和日间/夜间血压目标均未变化。除基线ABP值以外,日间和夜间收缩压偏倚与肾脏转归呈线性相关性。当将第2次ABP检测到的夜间收缩压水平纳入时,患者风险分类有所改善(净分类改善0.224)。第一次和第二次ABP检测在靶标以上的患者肾脏风险较大。

原始出处

Minutolo R1, Gabbai FB2, Chiodini P2, Garofalo C2, Stanzione G2, Liberti ME2, Pacilio M2, Borrelli S2, Provenzano M2, Conte G2, Nicola L2.Reassessment of Ambulatory Blood Pressure Improves Renal Risk Stratification in Nondialysis Chronic Kidney Disease: Long-Term Cohort Study.Hypertension. 2015 Jul 6.

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